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MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION

MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
淋巴细胞功能的分子遗传学分析
批准号：
3790745
负责人：
D H MARGULIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3790745
关键词：
MHC class I antigen T cell receptor T lymphocyte antigens chemical binding endopeptidases gene expression genetic manipulation genetic translation genetically modified animals histocompatibility antigens histocompatibility gene hybridomas immunogenetics laboratory mouse leukocyte activation /transformation lymphocyte major histocompatibility complex membrane activity membrane proteins molecular cloning molecular genetics protein engineering protein sequence protein structure function receptor binding recombinant DNA tissue /cell culture

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英文摘要
The focus of this laboratory has been the MHC class I molecule, classically considered a molecular heterodimer consisting of a 46 kd polymorphic heavy chain, exemplified by the murine H-2K, D, and L molecules (analogous to the human HLA-A, -B, and -C molecules), that is non-covalently assembled with the 12 kd monomorphic light chain, beta2-microglobulin. Our objectives under this project title have been to evaluate: 1) the influence of beta2-microglobulin and serum proteases on functional and biochemical binding of MHC class I molecules to antigenic peptides; 2) the expression and function of domain and sub-domain fragments of class I molecules generated by recombinant DNA methods, and expressed in tissue culture cells; 3) the function of soluble MHC class I molecules in a transgenic mouse model system; and 4) the production and function of single chain MHC class I molecules.
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IN VITRO MEASUREMENT OF BINDING OF SELF AND ANTIGENIC PEPTIDES TO MHC MOLECULES
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
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