BIOLOGY OF HUMAN AIDS RETROVIRUS

人类艾滋病逆转录病毒的生物学

基本信息

项目摘要

Human immunodeficiency virus (HIV) infection is associated with several different clinical syndromes including immunosuppression, Kaposi's sarcoma, wasting syndrome, and neurological abnormalities such as dementia. The goal of this project is to understand the role of variation in the viral genes in causing these diverse syndromes. We recently showed that HIV strains with ability to infect macrophages shared a strong homology in the amino acid sequences of their envelope proteins in the hypervariable V3 region. Other work has now confirmed that such macrophage-tropic HIV strains appear to be the main ones sexually transmitted between different individuals. The wide diversity of V3 sequences seen at later disease stages appears to evolve independently in each infected individual. Thus, the macrophage-tropic envelope consensus sequence may be an ideal target to which potential vaccines should be directed. In more recent studies we have analyzed V3 envelope sequences from a group of AIDS patients with and without HIV dementia. Whereas brain derived HIV from both groups appeared to be closely related to macrophage-tropic HIV strains, viruses from demented patients showed significant differences from those from non-demented patients. These results suggested that HIV dementia might be caused by a unique subset of macrophage-tropic HIV strains. The ability of primary AIDS patient HIV isolates and laboratory-adapted HIV isolates to infect cells in vitro was studied using HeLa-CD4 clones expressing differing amounts of CD4. Laboratory-adapted HIV showed a similar level of infectivity over a wide range of CD4 expression. In contrast, infectivity of primary patient HIV isolates was directly proportional to the amount of CD4 expressed on HeLa cells. These results demonstrate important functional differences in the envelope genes of primary patient HIV isolates which could be involved in various in vivo pathogenic effects.
人类免疫缺陷病毒(HIV)感染与几种疾病有关

项目成果

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B CHESEBRO的其他文献

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{{ truncateString('B CHESEBRO', 18)}}的其他基金

IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
马传染性贫血病毒(艾滋病逆转录病毒模型)的免疫生物学
  • 批准号:
    4688533
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
马传染性贫血病毒(艾滋病逆转录病毒模型)的免疫生物学
  • 批准号:
    3960601
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOLOGY OF HUMAN AIDS RETROVIRUS
人类艾滋病逆转录病毒的生物学
  • 批准号:
    3822091
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOLOGY OF HUMAN AIDS RETROVIRUS
人类艾滋病逆转录病毒的生物学
  • 批准号:
    3818247
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
鼠友白血病病毒的发病机制和恢复机制
  • 批准号:
    2566698
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
马传染性贫血病毒(艾滋病逆转录病毒模型)的免疫生物学
  • 批准号:
    3818225
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOLOGY OF HUMAN AIDS RETROVIRUS
人类艾滋病逆转录病毒的生物学
  • 批准号:
    2566777
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOLOGY OF HUMAN AIDS RETROVIRUS
人类艾滋病逆转录病毒的生物学
  • 批准号:
    3790761
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
鼠友白血病病毒的发病机制和恢复机制
  • 批准号:
    6160542
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:
BIOLOGY OF HUMAN AIDS RETROVIRUS
人类艾滋病逆转录病毒的生物学
  • 批准号:
    6160616
  • 财政年份:
  • 资助金额:
    --
  • 项目类别:

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抗人 CD4 分子的小鼠单克隆抗体生成单克隆蚂蚁
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MOUSE MONOCLONAL ANTIBODIES AGAINST HUMAN CD4 MOLECULE GENERATE MONOCLONAL ANT
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