BIOLOGY OF HUMAN AIDS RETROVIRUS
人类艾滋病逆转录病毒的生物学
基本信息
- 批准号:3746544
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AIDS dementia complex CD4 molecule HIV infections HeLa cells drug resistance genetic mapping genetic polymorphism histocompatibility gene host organism interaction human immunodeficiency virus human tissue macrophage microorganism culture protein sequence virulence virus envelope virus genetics virus infection mechanism
项目摘要
Human immunodeficiency virus (HIV) infection is associated with several
different clinical syndromes including immunosuppression, Kaposi's
sarcoma, wasting syndrome, and neurological abnormalities such as
dementia. The goal of this project is to understand the role of
variation in the viral genes in causing these diverse syndromes.
We recently showed that HIV strains with ability to infect macrophages
shared a strong homology in the amino acid sequences of their envelope
proteins in the hypervariable V3 region. Other work has now confirmed
that such macrophage-tropic HIV strains appear to be the main ones
sexually transmitted between different individuals. The wide diversity
of V3 sequences seen at later disease stages appears to evolve
independently in each infected individual. Thus, the macrophage-tropic
envelope consensus sequence may be an ideal target to which potential
vaccines should be directed.
In more recent studies we have analyzed V3 envelope sequences from a
group of AIDS patients with and without HIV dementia. Whereas brain
derived HIV from both groups appeared to be closely related to
macrophage-tropic HIV strains, viruses from demented patients showed
significant differences from those from non-demented patients. These
results suggested that HIV dementia might be caused by a unique subset
of macrophage-tropic HIV strains.
The ability of primary AIDS patient HIV isolates and laboratory-adapted
HIV isolates to infect cells in vitro was studied using HeLa-CD4 clones
expressing differing amounts of CD4. Laboratory-adapted HIV showed a
similar level of infectivity over a wide range of CD4 expression. In
contrast, infectivity of primary patient HIV isolates was directly
proportional to the amount of CD4 expressed on HeLa cells. These results
demonstrate important functional differences in the envelope genes of
primary patient HIV isolates which could be involved in various in vivo
pathogenic effects.
人类免疫缺陷病毒(HIV)感染与几种疾病有关
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('B CHESEBRO', 18)}}的其他基金
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
马传染性贫血病毒(艾滋病逆转录病毒模型)的免疫生物学
- 批准号:
4688533 - 财政年份:
- 资助金额:
-- - 项目类别:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
马传染性贫血病毒(艾滋病逆转录病毒模型)的免疫生物学
- 批准号:
3960601 - 财政年份:
- 资助金额:
-- - 项目类别:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
鼠友白血病病毒的发病机制和恢复机制
- 批准号:
2566698 - 财政年份:
- 资助金额:
-- - 项目类别:
IMMUNOBIOLOGY OF EQUINE INFECTIOUS ANEMIA VIRUS, A RETROVIRUS MODEL FOR AIDS
马传染性贫血病毒(艾滋病逆转录病毒模型)的免疫生物学
- 批准号:
3818225 - 财政年份:
- 资助金额:
-- - 项目类别:
MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS
鼠友白血病病毒的发病机制和恢复机制
- 批准号:
6160542 - 财政年份:
- 资助金额:
-- - 项目类别:
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