STUDY OF THE CLINICAL COURSE, PATHOGENESIS AND TREATMENT OF SEPTIC SHOCK

感染性休克是一种综合征，由身体对 微生物或其有毒产品。感染性休克的发生率 一直在稳步增长。它的死亡率为40%到90% 并已成为重症监护病房死亡的首要原因 在美国的单位。该综合征的病理生理学是 非常复杂；一系列外源性毒素和内源性毒素 介体可能导致进行性多系统器官衰竭 从几个小时到几天，通过仍然很差的机制 明白了。在过去的12年里，NIH感染性休克方案(82- CC-123)对病理生理学产生了重要的见解， 感染性休克的自然病史和治疗。根据协议， 对成人和儿童患者的调查仍在继续 败血症的心脏和外周血管表现(使用 超声心动图和前臂血流测量)，相互作用 脓毒症综合征的外源性和内源性介质(使用 败血症患者的血液标本和非败血症对照 患者)，以及脓毒症相关成人呼吸道的发病机制 窘迫综合征(使用支气管肺泡灌洗)。

Septic shock is a syndrome produced by the body's response to microorganisms or their toxic products. The incidence of septic shock has been increasing steadily. It carries a mortality of 40 to 90 percent and has become the leading cause of death in intensive care units in the United States. The pathophysiology of the syndrome is remarkably complex; an array of exogenous toxins and endogenous mediators may lead to progressive multi-system organ failure during a period of hours to days, through mechanisms that are still poorly understood. Over the past 12 years, the NIH Septic Shock Protocol (82- CC-123) has produced important insights into the pathophysiology, natural history, and therapy of septic shock. Under the protocol, investigations are continuing, in adult and pediatric patients, of the cardiac and peripheral vascular manifestations of sepsis (using echocardiography and measurement of forearm blood flow), the interplay of exogenous and endogenous mediators of the sepsis syndrome (using blood specimens drawn from septic patients and nonseptic control patients), and the pathogenesis of sepsis-related adult respiratory distress syndrome (using bronchoalveolar lavage).