STUDY OF THE CLINICAL COURSE, PATHOGENESIS AND TREATMENT OF SEPTIC SHOCK

感染性休克的临床病程、发病机制及治疗研究

• 批准号: 3752174
• 负责人: R E CUNNION
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752174
• 关键词: adult human (21+); adult respiratory distress syndrome; blood flow measurement; child (0-11); diagnostic respiratory lavage; echocardiography; human subject; human therapy evaluation; microorganism disease chemotherapy; pathologic process; respiratory disorder chemotherapy; shock

Septic shock is a syndrome produced by the body's response to microorganisms or their toxic products. The incidence of septic shock has been increasing steadily. It carries a mortality of 40 to 90 percent and has become the leading cause of death in intensive care units in the United States. The pathophysiology of the syndrome is remarkably complex; an array of exogenous toxins and endogenous mediators may lead to progressive multi-system organ failure during a period of hours to days, through mechanisms that are still poorly understood. Over the past 12 years, the NIH Septic Shock Protocol (82- CC-123) has produced important insights into the pathophysiology, natural history, and therapy of septic shock. Under the protocol, investigations are continuing, in adult and pediatric patients, of the cardiac and peripheral vascular manifestations of sepsis (using echocardiography and measurement of forearm blood flow), the interplay of exogenous and endogenous mediators of the sepsis syndrome (using blood specimens drawn from septic patients and nonseptic control patients), and the pathogenesis of sepsis-related adult respiratory distress syndrome (using bronchoalveolar lavage).

感染性休克是身体对感染的反应而产生的一种综合征 微生物或其有毒产物。感染性休克的发生率 一直在稳步增长。它的死亡率为 40 至 90 % 并已成为重症监护室死亡的主要原因 美国境内的单位。该综合征的病理生理学是 非常复杂；一系列外源性毒素和内源性毒素 介质可能导致进行性多系统器官衰竭 几小时到几天的时间，通过仍然很差的机制 明白了。在过去 12 年中，NIH 脓毒性休克方案 (82- CC-123）对病理生理学产生了重要的见解， 自然史和感染性休克的治疗。根据协议， 对成人和儿童患者的研究仍在继续 脓毒症的心脏和外周血管表现（使用 超声心动图和前臂血流量测量），相互作用 脓毒症综合征的外源性和内源性介质（使用 从脓毒症患者和非脓毒症对照中抽取的血液样本 患者），以及脓毒症相关成人呼吸道疾病的发病机制 窘迫综合征（使用支气管肺泡灌洗）。