STUDY OF THE CLINICAL COURSE, PATHOGENESIS AND TREATMENT OF SEPTIC SHOCK

感染性休克的临床病程、发病机制及治疗研究

• 批准号: 5201087
• 负责人: R E CUNNION
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201087
• 关键词: adult human (21+); adult respiratory distress syndrome; blood toxicology; child (0-11); diagnostic respiratory lavage; echocardiography; human subject; human therapy evaluation; microorganism disease chemotherapy; pathologic process; respiratory disorder chemotherapy; septic shock

Septic shock is a syndrome produced by the body's response to microorganisms or their toxic products. The incidence of septic shock has been increasing steadily. It carries a mortality of 40 to 90 percent and has become the leading cause of death in intensive care units in the United States. The pathophysiology of the syndrome is remarkably complex; an array of exogenous toxins and endogenous mediators may lead to progressive multi-system organ failure during a period of hours to days, through mechanisms that are still poorly understood. Over the past 12 years, the NIH Septic Shock Protocol (82-CC-123) has produced important insights into the pathophysiology, natural history, and therapy of septic shock. Under the protocol, investigations are continuing, in adult and pediatric patients, of the cardiac and peripheral vascular manifestations of sepsis (using echocardiography and measurement of forearm blood flow), the interplay of exogenous and endogenous mediators of the sepsis syndrome (using blood specimens drawn from septic patients and nonseptic control patients), and the pathogenesis of sepsis-related adult respiratory distress syndrome (using bronchoalveolar lavage).

感染性休克是一种综合征，由身体对 微生物或其有毒产品。感染性休克的发生率 一直在稳步增长。它的死亡率为40%到90%， 已经成为世界上重症监护病房死亡的首要原因 美国。该综合征的病理生理异常复杂； 一系列外源性毒素和内源性介体可能导致 从几小时到几天的进行性多系统器官衰竭， 通过仍鲜为人知的机制。在过去12年中 多年来，NIH感染性休克方案(82-CC-123)已经产生了重要的 对脓毒症的病理生理学、自然病史和治疗的见解 令人震惊。根据议定书，调查仍在继续，成人和 儿科患者心脏和外周血管的表现 脓毒症(使用超声心动图和前臂血流测量)， 脓毒症综合征的外源性和内源性介质的相互作用 (使用来自败血症患者和非败血症对照的血液样本 患者)，以及脓毒症相关成人呼吸道的发病机制 窘迫综合征(使用支气管肺泡灌洗)。