REEVALUATION OF LONG-TERM SURVIVORS WITH DILATED CARDIOMYOPATHY

扩张型心肌病长期幸存者的重新评估

• 批准号: 2571307
• 负责人: R E CUNNION
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2571307
• 关键词: antiinflammatory agents; case history; cineangiocardiography; clinical research; echocardiography; heart dimension /size; heart disorder chemotherapy; heart function; human subject; human therapy evaluation; idiopathic dilated cardiomyopathy; longitudinal human study; pathologic process; radionuclide imaging /scanning; remission /regression

Between 1982 and 1988 the National Heart, Lung, and Blood Institute, the National Institute of Allergy and Infectious Diseases, and the Clinical Center conducted a prospective randomized trial of anti- inflammatory therapy in idiopathic dilated cardiomyopathy. By 1992, after 6 to 9 years of followup, 67 of the 123 patients had died and another 23 had undergone cardiac transplantation. Of the remaining 33 nontransplanted survivors, almost half were asymptomatic. This protocol (93-CC-0096)involves noninvasive followup re-evaluation of these 33 patients, including radionuclide cineangiography, echocardiography, Holter monitoring, and exercise testing. To date, 8 of the 33 patients have been restudied. When completed, this study will represent the first prospective description of the long-term natural history of idiopathic dilated cardiomyopathy in a well-characterized cohort of referral patients. Objective data concerning cardiac size and cardiac function among long-term survivors will permit clinicians to advise newly diagnosed dilated cardiomyopathy patients regarding their prospects for long-term remission.

1982年至1988年，美国国家心肺血液研究所， 国家过敏和传染病研究所，以及 临床中心进行了一项前瞻性随机试验， 特发性扩张型心肌病的炎症治疗到1992年， 经过6 - 9年的随访，123名患者中有67人死亡， 另有23人接受了心脏移植。剩余 33名非移植存活者几乎一半无症状这 方案（93-CC-0096）涉及无创随访重新评价 这33例患者，包括放射性核素电影血管造影， 超声心动图、霍尔特监测和运动试验。 迄今为止，33例患者中有8例接受了再研究。完成后， 这项研究将代表第一个前瞻性描述的 特发性扩张型心肌病的长期自然病史 特征明确的转诊患者队列。客观数据 关于心脏大小和心脏功能， 幸存者将允许临床医生建议新诊断的扩张 心肌病患者的长期前景 缓解。