REEVALUATION OF LONG-TERM SURVIVORS WITH DILATED CARDIOMYOPATHY

工作总结：1982至1988年间，NHLBI、NIAID和 临床中心进行了一项前瞻性随机试验 特发性扩张型心肌病的炎症治疗。到1992年， 经过6至9年的随访，123名患者中有67人死亡， 另有23人接受了心脏移植。在剩下的33个人中 未移植的幸存者中，近一半没有症状。该协议 (93-CC-0096)涉及对这33例患者的非侵入性随访重新评估 患者，包括放射性核素电影血管造影，超声心动图， 动态心电监测和运动试验。 到目前为止，33名患者中有8名已经进行了重新研究。完成后，这 研究将代表对长期的前瞻性描述的第一次 特发性扩张型心肌病的自然病史- 以转诊患者为特征的队列。有关的客观数据 长期存活者的心脏大小和心脏功能将允许 临床医生建议新诊断的扩张型心肌病患者 关于他们长期缓解的前景。

Summary of Work: Between 1982 and 1988, the NHLBI, the NIAID, and the Clinical Center conducted a prospective, randomized trial of anti- inflammatory therapy in idiopathic dilated cardiomyopathy. By 1992, after 6 to 9 years of followup, 67 of the 123 patients had died and another 23 had undergone cardiac transplantation. Of the remaining 33 non-transplanted survivors, almost half were asymptomatic. This protocol (93-CC-0096)involves non-invasive followup re-evaluation of these 33 patients, including radionuclide cineangiography, echocardiography, Holter monitoring, and exercise testing. To date, 8 of the 33 patients have been restudied. When completed, this study will represent the first prospective description of the long-term natural history of idiopathic dilated cardiomyopathy in a well- characterized cohort of referral patients. Objective data concerning cardiac size and cardiac function among long-term survivors will permit clinicians to advise newly diagnosed dilated cardiomyopathy patients about their prospects for long-term remission.