REEVALUATION OF LONG-TERM SURVIVORS WITH DILATED CARDIOMYOPATHY

在1982至1988年间，NHLBI、NIAID和临床中心 年进行了一项抗炎治疗的前瞻性随机试验 特发性延迟性心肌病。到1992年，在经历了6到9年的 随访中，123名患者中有67名死亡，另有23名患者接受了 心脏移植。在剩下的33名未移植的幸存者中， 几乎一半的人没有症状。该协议(93-CC-OO96)涉及非 对这33名患者的有创随访重新评估，包括 放射性核素电影心血管造影、超声心动图、动态心动图监测和 运动测试。 完成后，这项研究将代表第一个预期 描述长期自然病史的特发性扩张症 一组特征良好的转诊患者中的心肌病。 长寿人群心脏大小和心功能的客观资料 长期存活者将允许临床医生建议新诊断的扩张 关于心肌病患者长期缓解的前景。

Between 1982 and 1988 the NHLBI, the NIAID, and the Clinical Center conducted a prospective randomized trial of anti-inflammatory therapy in idiopathic delated cardiomyopathy. By 1992, after 6 to 9 years of followup, 67 of the 123 patients had died and another 23 had undergone cardiac transplantation. Of the remaining 33 non-transplanted survivors, almost half were asymptomatic. This protocol (93-CC-OO96) involves non- invasive followup re-evaluation of these 33 patients, including radionuclide cineangiography echocardiography, Holter monitoring, and exercise testing. When completed, this study will represent the first prospective description of the long-term natural history idiopathic dilated cardiomyopathy in a well-characterized cohort of referral patients. Objective data concerning cardiac size and cardiac function among long- term survivors will permit clinicians to advise newly diagnosed dilated cardiomyopathy patients regarding their prospects for long-term remission.