REEVALUATION OF LONG-TERM SURVIVORS WITH DILATED CARDIOMYOPATHY

扩张型心肌病长期幸存者的重新评估

• 批准号: 3752173
• 负责人: R E CUNNION
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752173
• 关键词: angiography; antiinflammatory agents; cardiovascular stress test; case history; cineangiocardiography; echocardiography; heart dimension /size; heart disorder chemotherapy; heart function; human subject; human therapy evaluation; hypertrophic myocardiopathy; longitudinal human study; myocardium disorder; pathologic process; prognosis; radionuclide imaging /scanning; remission /regression

Between 1982 and 1988 the NHLBI, the NIAID, and the Clinical Center conducted a prospective randomized trial of anti-inflammatory therapy in idiopathic delated cardiomyopathy. By 1992, after 6 to 9 years of followup, 67 of the 123 patients had died and another 23 had undergone cardiac transplantation. Of the remaining 33 non-transplanted survivors, almost half were asymptomatic. This protocol (93-CC-OO96) involves non- invasive followup re-evaluation of these 33 patients, including radionuclide cineangiography echocardiography, Holter monitoring, and exercise testing. When completed, this study will represent the first prospective description of the long-term natural history idiopathic dilated cardiomyopathy in a well-characterized cohort of referral patients. Objective data concerning cardiac size and cardiac function among long- term survivors will permit clinicians to advise newly diagnosed dilated cardiomyopathy patients regarding their prospects for long-term remission.

1982年至1988年间，NHLBI， NIAID和临床中心