REEVALUATION OF LONG-TERM SURVIVORS WITH DILATED CARDIOMYOPATHY

扩张型心肌病长期幸存者的重新评估

• 批准号: 5201086
• 负责人: R E CUNNION
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5201086
• 关键词: angiography; antiinflammatory agents; cardiovascular stress test; case history; cineangiocardiography; echocardiography; heart dimension /size; heart disorder chemotherapy; heart function; human subject; human therapy evaluation; hypertrophic myocardiopathy; longitudinal human study; pathologic process; population survey; radionuclide imaging /scanning; remission /regression

Between 1982 and 1988 the NHLBI, the NIAID, and the Clinical Center conducted a prospective randomized trial of anti-inflammatory therapy in idiopathic dilated, after 6 to 9 years of followup, 67 of the 123 patients had died and another 23 had undergone cardiac transplantation. Of the remaining 33 non-transplanted survivors, almost half were asymptomatic. This protocol (93-CC-0096)involves non-invasive followup re-evaluation of these 33 patients, including radionuclide cineangiography, echocardiography, Holter monitoring, and exercise testing. During FY1994, the status of all 33 patients was reconfirmed by mail and telephone surveys. Travel funds became available, and the first 3 patients underwent inpatient study at the Clinical Center. When completed, this study will represent the first prospective description of the long-term natural history of idiopathic dilated cardiomyopathy in a well-characterized cohort of referral patients. Objective data concerning cardiac size and cardiac function among long- term survivors will permit clinicians to advise newly diagnosed dilated cardiomyopathy patients regarding their prospects for long-term remission.

在1982至1988年间，NHLBI、NIAID和临床中心 年进行了一项抗炎治疗的前瞻性随机试验 经过6到9年的随访，123名患者中有67名特发性扩张 已经死亡，另外23人接受了心脏移植。中的 其余33名未移植的幸存者中，几乎一半没有症状。 该方案(93-CC-0096)涉及对 这33名患者，包括放射性核素电影血管造影术， 超声心动图、动态心动图监测和运动试验。 在1994财年，所有33名患者的状况都通过邮寄和 电话调查。旅行资金开始到位，第一批3名患者 在临床中心接受住院研究。 完成后，这项研究将代表第一个预期 特发性扩张症的长期自然病史描述 一组特征良好的转诊患者中的心肌病。 长寿人群心脏大小和心功能的客观资料 长期存活者将允许临床医生建议新诊断的扩张 关于心肌病患者长期缓解的前景。