NONINVASIVE DETERMINATION OF LEFT ATRIAL PRESSURE AND TOTAL VASCULAR RESISTANCE

无创测定左心房压力和总血管阻力

• 批准号: 3896252
• 负责人: R E CUNNION
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3896252
• 关键词: congestive heart failure; critical care; diagnosis design /evaluation; echocardiography; human subject; intracardiac pressure; noninvasive diagnosis; shock; vascular resistance

Left atrial pressure is a measure of a patient's volume status, and serves as a guide to the use of fluid, diuretic, and vasopressor therapy in patients with congestive heart failure, shock, and various other hemodynamic derangements. Left atrial pressure conventionally is measured invasively, by transvenous placement of a pulmonary artery catheter, with the pulmonary artery wedge pressure taken as an indirect reflection of left atrial pressure. This invasive measurement technique entails considerable cost and some potential morbidity. Total vascular resistance is a measure of a patient's vascular tone, and is used to aid management of shock states. Ordinarily it is measured by obtaining simultaneously a cardiac output (from an indwelling thermodilution pulmonary artery catheter) and an arterial pressure (from an indwelling intra-arterial catheter). Advances in the state of the art of cross-sectional and Doppler echocardiography have permitted the formulation of techniques for non- invasive calculation of left atrial pressure and total vascular resistance. These techniques have not yet been validated, however, in a critical care unit patient population. In the past year, we have performed bedside echocardiography in approximately 40 patients for the purpose of validating these techniques. Should the techniques prove reliable, the need for invasive techniques may be ameliorated significantly. Further, if the techniques are sufficiently precise, they have promise as an investigative tool in subsequent studies of fluid, vasopressor, and vasodilator therapy both in critical care units and in ambulatory patient populations.

左房压是衡量病人容积状态的一种指标