MECHANICAL PROSTHETIC HEART VALVE TESTER

机械人工心脏瓣膜测试仪

• 批准号: 3789392
• 负责人: T L TALBOT
• 金额: --
• 依托单位: NATIONAL CENTER FOR RESEARCH RESOURCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789392
• 关键词: aortic valve; bioengineering /biomedical engineering; biomaterial evaluation; blood pressure; heart sonography; noninvasive diagnosis; prosthetic heart valve; ultrasound blood flow measurement

Six different manufacturers' prosthetic heart valves were tested and ranked according to performance indices described by Swanson and Gabbay. Additionally, a technique was devised whereby the pressure drop across the aortic valve could be predicted by velocity measurements made with continuous-wave Doppler (CWD) imaging. The results of preliminary in vitro studies demonstrate a high correlation (r>0.9) between the peak velocity as measured with CWD and the predicted velocity obtained by the application of a simplified Bernoulli equation, which uses a measured maximum pressure drop across the aortic valve. Also, an acoustical signature analysis technique is under investigation for possible noninvasive detection of partially failed single-leaflet-type mechanical valves.

对六家不同制造商的人工心脏瓣膜进行了测试， 根据Swanson和Gabbay描述的性能指标进行排名。 此外，还设计了一种技术， 主动脉瓣可以通过测量流速来预测， 连续波多普勒（CWD）成像。 初步结果在 体外研究表明，峰之间的高度相关性（r>0.9 用CWD测量的速度和由CWD获得的预测速度 应用简化的伯努利方程，它使用测量的 主动脉瓣的最大压降 此外，声学 签名分析技术正在研究中， 非侵入性检测部分失效的单小叶型机械 阀门.