ASSESSMENT OF SCRATCHING IN BILIARY CIRRHOSIS PATIENTS

胆汁性肝硬化患者抓挠的评估

• 批准号: 3789402
• 负责人: T L TALBOT
• 金额: --
• 依托单位: NATIONAL CENTER FOR RESEARCH RESOURCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789402
• 关键词: analytical method; biomedical equipment development; electrical measurement; human subject; patient monitoring device; personal computers; primary biliary cirrhosis; pruritis; radiowave radiation

Patients with primary biliary cirrhosis suffer from severe bouts of itching, manifested by chronic scratching. In order to evaluate the efficacy of experimental drugs that may relieve the itching, it is necessary to quantify the scratching. A piezoelectric foil cemented to the patient's primary scratching fingernail transduced mechanical vibrations generated by the scratching into an electrical signal, which was applied to the input of a miniature FM transmitter. After the signal was obtained with an FM receiver, it was processed by a custom-designed frequency counter, which in turn was interrogated and reset periodically by a personal computer. The study consisted of measurement periods of six to eight hours, both before treatment and after treatment with specific drugs. Each patient served as his or her own control.

原发性胆汁性肝硬化的患者患有严重的 瘙痒，表现为慢性抓挠。 为了评价 实验药物的疗效，可能会缓解瘙痒，它是 来量化抓痕 一种压电箔， 患者的主要抓挠指甲被转换为机械 将刮擦产生的振动转化为电信号， 应用于微型调频发射机的输入端。 直至风球 是用调频接收器获得的，它是由定制设计的 频率计数器，该计数器又被周期性地询问和重置 通过个人电脑。 该研究包括以下测量期： 治疗前和治疗后6至8小时， 具体药物。 每名患者作为其自身对照。