WOUND HEALING--BIOLOGY AND RHEOLOGY

伤口愈合——生物学和流变学

• 批准号: 3789388
• 负责人: T L TALBOT
• 金额: --
• 依托单位: NATIONAL CENTER FOR RESEARCH RESOURCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3789388
• 关键词: biological models; biomechanics; injury /disease stressor; laboratory rat; nonblood rheology; skin; skin neoplasms; swine; tensile strength; wound healing

Preliminary studies have been completed with swine models. These studies involved stamping an indelible grid (10 cm x 10 cm) on the skin of an anesthetized swine, excising a strip of the skin (1 cm x 10 cm) out of the grid area, and approximating the incision edges with silk sutures. Photographs of the grid were taken before excision, after excision, and after suturing. These photographs are being analyzed to determine the impressed strain on the wound closure, and eventually to relate this information to wound breaking strength (WBS). Studies based on an anesthetized rat model that relates biological and pharmacological interventions to WBS have been completed. Certain groups were treated pharmacologically during the wound-healing process. Significant decrease in WBS was observed in these groups, compared to control groups. Further studies will include the comparison of a tumor-bearing group to control groups.

猪模型的初步研究已经完成。 这些研究 涉及在皮肤上印上不可磨灭的网格（10 厘米 x 10 厘米） 麻醉猪，从猪身上切下一条皮（1 cm x 10 cm） 网格区域，并用丝线缝合切口边缘。 网格的照片拍摄于切除前、切除后以及 缝合后。 正在分析这些照片以确定 对伤口闭合施加压力，并最终将其联系起来 伤口断裂强度 (WBS) 的信息。 基于麻醉大鼠模型的研究，该模型将生物学和 WBS 的药物干预已经完成。 某些团体 在伤口愈合过程中接受药物治疗。 与其他组相比，这些组中的 WBS 显着下降 对照组。 进一步的研究将包括比较 荷瘤组与对照组。