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CEREBRAL ISCHEMIA AND EDEMA--BIOGENIC AMINES

CEREBRAL ISCHEMIA AND EDEMA--BIOGENIC AMINES
脑缺血和水肿--生物胺
批准号：
3782343
负责人：
M SPATZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3782343
关键词：
amines brain edema brain metabolism cerebral ischemia /hypoxia dopamine enzyme mechanism free radicals gerbil /jird mitochondria neurotransmitter metabolism serotonin

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中文摘要
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英文摘要
The association of changes in the metabolic pathway of monoamines (dopamine and 5-hydroxy-tryptamine) with mitochondrial enzyme systems which are involved in the production and removal of free radicals formed during dopamine metabolism and formation of edema was investigated in bilateral brain ischemia in gerbils. The results suggest that the involvement of dopamine-derived free radicals in brain edema is unlikely in early reflow, because imbalance between H2O2~producing reactions of dopamine metabolism and mitochondrial antioxidative capacity does not occur prior to 1 hr reflow after 15 min of bilateral ischemia in gerbils. However, the findings of this study reinforce the participation of 5- hydroxytryptamine in the formation of ischemic brain edema.
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CEREBRAL ISCHEMIA--ENDOTHELIN-1 AND NITRIC OXIDE
ISCHEMIC BRAIN EDEMA--EFFECT OF Y-HYDROXYBUTYRATE ON S2-RECEPTOR BINDING SITES
INVESTIGATION OF EXTRANEURONAL CATECHOL SYNTHESIZING ENZYMES IN THE CNS
THE ESTABLISHMENT OF CEREBROVASCULAR SMOOTH MUSCLE CULTURE
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