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PROSTAGLANDIN RECEPTORS IN CULTURED GLIA AND CEREBROMICROVASCULAR SMOOTH MUSCLE

PROSTAGLANDIN RECEPTORS IN CULTURED GLIA AND CEREBROMICROVASCULAR SMOOTH MUSCLE
培养的神经胶质细胞和脑微血管平滑肌中的前列腺素受体
批准号：
3968950
负责人：
M SPATZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3968950
关键词：
adenylate cyclase arachidonate blood brain barrier blood pressure brain circulation cerebral cortex cerebrovascular system cyclic AMP electron microscopy fatty acid biosynthesis fluorescence glia histochemistry /cytochemistry microcirculation microscopy organ culture prostaglandin E prostaglandin F prostaglandins radioimmunoassay vascular endothelium vascular endothelium permeability vascular smooth muscle

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中文摘要
翻译
前列腺素（PGE1，PGE2，PGF1 α，PGF2 α，PGD2）对 腺苷酸环化酶（AC）在血管平滑肌 肌肉和神经胶质细胞培养。 PGE1和PGE2，与PGF1和 PGF 2刺激两种细胞类型中的cAMP形成。 平滑肌AC 系统对E型野牡丹素的亲和力比AC系统高 神经胶质细胞中的系统。 最重要的是，剂量依赖性PGI2，但不是 PGD2增强cAMP的形成，表现在平滑肌中， 胶质细胞中PGI_2和PGD_2的AC反应呈反向。 这些 研究结果表明，与AC相连的前列腺素受体是 不同的细胞类型。
英文摘要
The effect of prostaglandins (PGE1, PGE2, PGF1Alpha, PGF2Alpha, PGD2) on adenylate cyclase (AC) was investigated in cerebromicrovascular smooth muscle and glial cell cultures. PGE1 and PGE2, in contrast to PGF1 and PGF2, stimulated cAMP formation in both cell types. The smooth muscle AC system showed a greater affinity for E-type prostaglandins than the AC system in glial cells. Most importantly, a dose-dependent PGI2, but not PGD2 enhancement of cAMP formation, was manifested in smooth muscle while a reverse AC reactivity of PGI2 and PGD2 was seen in glial cells. These findings indicate that the prostaglandin receptors linked to AC are distinct in each cell type.
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会议论文
ISCHEMIC BRAIN EDEMA--EFFECT OF Y-HYDROXYBUTYRATE ON S2-RECEPTOR BINDING SITES
CEREBRAL PROSTAGLANDIN & ADENOSINE RECEPTORS LINKED TO ADENYLATE CYCLASE
THE ESTABLISHMENT OF CEREBROVASCULAR SMOOTH MUSCLE CULTURE
PROSTAGLANDIN SYNTHESIS IN CULTURED CEREBROMICROVASCULAR AND GLIAL CELLS
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