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INVESTIGATION OF EXTRANEURONAL CATECHOL SYNTHESIZING ENZYMES IN THE CNS

INVESTIGATION OF EXTRANEURONAL CATECHOL SYNTHESIZING ENZYMES IN THE CNS
中枢神经系统外儿茶酚合成酶的研究
批准号：
4696910
负责人：
M SPATZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4696910
关键词：
catecholamines central nervous system cerebrovascular system epinephrine exoenzyme high performance liquid chromatography histochemistry /cytochemistry hormone biosynthesis hormone regulation /control mechanism microcirculation neurotransmitter metabolism norepinephrine tissue /cell culture vascular endothelium

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中文摘要
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英文摘要
Our previous immunohistochemical and biochemical studies of cerebral microvessels and cerebrovascular endothelial cultures showed the presence of phenylethanolamine-N-methyltransferase (PNMT) activity in both tissues. Since these extraneuronal tissues contain a catecholamine synthesizing enzyme which is responsible for conversion of norepinephrine to epinephrine, we extended these studies to determine whether vascular PNMT is indeed capable of producing epinephrine from norepinephrine. For this purpose a direct assay of endothelial epinephrine formed from norepinephrine was determined by using high pressure liquid chromatography. These studies, which are still in progress, have shown that the cultured cerebrovascular endothelium (2nd-4th generation) derived from dissociated cerebral microvascular fractions (obtained from rats) are capable of converting norepinephrine to epinephrine.
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