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CEREBRAL PROSTAGLANDIN & ADENOSINE RECEPTORS LINKED TO ADENYLATE CYCLASE

CEREBRAL PROSTAGLANDIN & ADENOSINE RECEPTORS LINKED TO ADENYLATE CYCLASE
脑前列腺素
批准号：
3945218
负责人：
M SPATZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3945218
关键词：
adenosine adenylate cyclase blood brain barrier brain circulation cerebral cortex cerebrovascular system cyclic AMP electron microscopy fatty acid biosynthesis fluorescence glia histochemistry /cytochemistry microcirculation microscopy neuropharmacology prostaglandin E prostaglandin F prostaglandins radioimmunoassay tissue /cell culture vascular endothelium vascular smooth muscle vasoactive agent

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中文摘要
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英文摘要
The interaction between adenosine and PGE2 receptors linked to adenylate cyclase was investigated in cultured endothelial cells derived from dissociated cerebral microvessels. PGE2 stimulated adenylate cyclase in dose dependent manner (1nm-100 mu M) while adenosine increased the activity of adenylate cyclase only at high concentration of the drug (0.01- 0.1mM). Increasing concentration of adenosine with PGE2 (10- 6M) had a statistically significant effect on adenylate cyclase stimulation only at lower doses of adenosine (1-10nM). The same concentrations of adenosine (1-10nM) alone did not enhance significantly the formation of cAMP. Those results indicate that both vasoactive substances adenosine and PGE2 have an effect on receptors linked to adenylate cyclase.
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CEREBRAL ISCHEMIA--ENDOTHELIN-1 AND NITRIC OXIDE
ISCHEMIC BRAIN EDEMA--EFFECT OF Y-HYDROXYBUTYRATE ON S2-RECEPTOR BINDING SITES
INVESTIGATION OF EXTRANEURONAL CATECHOL SYNTHESIZING ENZYMES IN THE CNS
THE ESTABLISHMENT OF CEREBROVASCULAR SMOOTH MUSCLE CULTURE
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