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VASOACTIVE SUBSTANCES--CARBOHYDRATE METABOLISMS IN CEREBROMICROVASCULAR ELEMENTS

VASOACTIVE SUBSTANCES--CARBOHYDRATE METABOLISMS IN CEREBROMICROVASCULAR ELEMENTS
血管活性物质--脑微血管元件中的碳水化合物代谢
批准号：
4696987
负责人：
M SPATZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4696987
关键词：
capillary carbohydrate metabolism cell type glycogen microcirculation serotonin tissue /cell culture vascular endothelium vascular smooth muscle vasoactive agent

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英文摘要
The separately cultured smooth muscle and endothelial cells derived from dissociated cerebral microvessels are characterized by high content of glycogen. Norepinephrine induces glycogenolysis while 5-hydroxytryptamine stimulates glycogenesis in both cell types. The endogenous glucose of the endothelium but not that of the smooth muscle serves as a direct source for the 5 HT enhancement of glycogen formation. Indomethacin, the known inhibitor of cyclooxygenase modulates the glycogen content in the smooth muscle only. These findings strongly suggest that the carbohydrate metabolism of each cell has a distinct control mechanism compatible with the underlying integral microvascular function.
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