CEREBRAL ISCHEMIA AND MONOAMINES

这项调查代表了一项持续的努力，以澄清 成人易感性高于成人的致病机制 幼年动物出现脑缺血。具体来说，这项研究是 5-羟色胺与突触体的关系 5-羟色胺释放与突触后5-羟色胺2-(S2)的动力学特性 成年和幼年蒙古沙土鼠大脑皮质中的受体 遭受相同的缺血伤害(双侧缺血[15分钟]， 无再循环[60min])。 结果显示，突触体5-羟色胺与 突触前功能释放与5-HT2-突触后的特性 成年和幼年沙土鼠脑缺血时的受体。只有增加的 突触体释放5-羟色胺对大鼠脑内皮细胞形态的影响 5-HT2-突触后受体。这些发现还表明， 观察到成年沙土鼠对脑缺血的易感性比 幼年动物的这一点与它们独特的神经元有关 功能。

This investigation represents a continuous effort to elucidate the pathomechanism responsible for the greater susceptibility of adult than young animals to cerebral ischemia. Specifically, this study was concerned with the relationship between synaptosomal 5-hydoxytryptamine (5-HT) release and the kinetic properties of 5-HT2- (S2) postsynaptic receptors in the cerebral cortex of adult and young Mongolian gerbils subjected to the same ischemic insult (bilateral ischemia [15 min] with and without recirculation [60 min]). The results show a close correlation between the synaptosomal 5-HT release (= presynaptic function) and properties of 5-HT2-postsynaptic receptors in ischemia of adult and young gerbils. Only the increased release of 5-HT from synaptosomes modulated the profile of 5-HT2-postsynaptic receptors. These findings also suggest that the observed greater susceptibility of adult gerbils to brain ischemia than that of the young animals is linked to their distinctive neuronal function.