SERUM CHOLESTEROL AND TRIGLYCERIDE VALUES OF THE NCRR WHHL RABBIT COLONY

NCRR WHHL 兔群的血清胆固醇和甘油三酯值

• 批准号: 3785621
• 负责人: D E BARNARD
• 金额: --
• 依托单位: NATIONAL CENTER FOR RESEARCH RESOURCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3785621
• 关键词: animal breeding; animal colony; animal population genetics; blood chemistry; blood lipid; cholesterol; disease /disorder model; familial hyperlipoproteinemia type II; gender difference; genotype; hyperlipidemia; laboratory rabbit; low density lipoprotein; triglycerides; veterinary science

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe heritable hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators requiring this animal model for use in human familial hypercholesterolemia due to a low density lipoprotein receptor defect. The purpose of this project is to characterize the serum cholesterol and triglyceride values of the NIH WHHL rabbit colony. Blood was collected from WHHL rabbits at eight weeks, three months, seven months, and twelve months of age. The serums were analyzed for lipoprotein cholesterol and triglycerides. A computer program has been developed to track pedigrees of the WHHL rabbits, making it possible to evaluate the influence of genotype on cholesterol and triglyceride values. Total serum cholesterol values range from 310 to 1251 mg/dl with a mean of 828 mg/dl. The low density lipoprotein (LDL) cholesterol values range from 70 to 1185 mg/dl with a mean of 630 mg/dl. Serum triglyceride values range from 107 to 959 mg/dl with a mean of 394 mg/dl. There appears to be a correlation between serum triglyceride concentration and the sex of the rabbit. The mean male and female triglyceride concentrations were 510 mg/dl and 309 mg/dl, respectively.

兽医资源计划、国家研究资源中心、 培育出渡边遗传性高脂血症（WHHL）兔 繁殖群 作为需要该动物模型用于以下研究的研究人员的资源 低密度脂蛋白引起的人类家族性高胆固醇血症 受体缺陷。 该项目的目的是表征血清胆固醇和 NIH WHHL 兔群的甘油三酯值。 已采集血液 来自八周、三个月、七个月和十二个月时的 WHHL 兔子 月龄。 分析血清中的脂蛋白胆固醇和 甘油三酯。 已经开发出一种计算机程序来追踪血统 WHHL 兔子的影响，从而可以评估 胆固醇和甘油三酯值的基因型。 总血清 胆固醇值范围为 310 至 1251 mg/dl，平均值为 828 mg/dl。 低密度脂蛋白 (LDL) 胆固醇值范围为 70 至 1185 毫克/分升，平均值为 630 毫克/分升。 血清甘油三酯值范围 从 107 至 959 mg/dl，平均值为 394 mg/dl。 似乎有一个 血清甘油三酯浓度与性别的相关性 兔子。 平均值 男性和女性甘油三酯浓度分别为 510 mg/dl 和 309 mg/dl， 分别。