CHARACTERIZATION OF THE WHHL RABBIT LIPOPROTEIN PHENOTYPES

WHHL 兔脂蛋白表型的表征

• 批准号: 3849377
• 负责人: D E BARNARD
• 金额: --
• 依托单位: NATIONAL CENTER FOR RESEARCH RESOURCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3849377
• 关键词: animal breeding; animal colony; atherosclerosis; blood lipoprotein; coronary disorder; disease /disorder model; electrophoresis; hyperlipoproteinemia; laboratory rabbit; phenotype; veterinary science

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators. Watanabe et al reported that there are two types of WHHL rabbits--those with early development and high incidence of coronary atherosclerosis (type 1) and those with late development and low incidence of coronary atherosclerosis (type 2). It has also been shown that either type of rabbit can be selectively bred to produce progeny exhibiting the phenotype of interest. Recently, it was reported that these two types of WHHL rabbits can be differentiated by their lipoprotein phenotypes. Electrophoretic analysis of 14 rabbits from the NIH WHHL rabbit colony showed that there are two lipoprotein phenotypes: one with an increased density of beta-lipoprotein and another with a beta-doublet. These phenotypes are similar to those reported for the two types of WHHL rabbits.

兽医资源计划，国家研究资源中心， 建立了一个渡边高脂血症（WHHL）兔繁殖群， 作为调查人员的资源。 Watanabe等人报告说， 两种类型的WHHL兔-那些具有早期发育和高 冠状动脉粥样硬化（1型）和晚期 冠状动脉粥样硬化（2型）的发展和低发病率。 它 还表明，任何一种兔子都可以选择性地繁殖， 产生表现出感兴趣的表型的后代。 近日有 报道，这两种类型的WHHL兔可以区分， 脂蛋白表型 14只家兔的电泳分析 从NIH WHHL兔群中发现，有两种脂蛋白 表型：一种是β-脂蛋白密度增加，另一种是 有β-双峰 这些表型与报告的 两种类型的WHHL兔。