SERUM CHOLESTEROL AND TRIGLYCERIDE VALUES OF THE NCRR WHHL RABBIT COLONY

兽医资源计划，国家研究资源中心， 建立了一只渡边遗传性高脂血症(WHHL)兔 繁育群体作为研究人员需要这种动物的资源 低密度脂蛋白引起的家族性高胆固醇血症模型 密度脂蛋白受体缺陷。这个项目的目的是 评价基因对血清胆固醇和血脂的影响 NIH WHHL兔的甘油三酯浓度。采集了血液 来自1991年和1994年的WHHL兔。1991年平均总血清 胆固醇和甘油三酯浓度分别为828和394 mg/dl， 分别进行了分析。血清胆固醇和甘油三酯的值在310 分别为1251 mg/dl和107~959 mg/dl。1994年的血清总量 胆固醇值在222至1356毫克/分升之间，平均值为572 Mg/dl。血清甘油三酯水平在134到1410毫克/分升之间， 平均值为423 mg/dl。1994年血清总胆固醇的下降是由于 降低一岁及以上的WHHL兔的浓度(406 mg/dl) 与1991年相同年龄的兔子相比(550毫克/分升)。

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe heritable hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators requiring this animal model for use in human familial hypercholesterolemia caused by a low density lipoprotein receptor defect. The purpose of this project is to evaluate the influence of genotype on the serum cholesterol and triglyceride concentrations of the NIH WHHL rabbits. Blood was collected from WHHL rabbits in 1991 and 1994. The 1991 mean total serum cholesterol and triglyceride concentrations were 828 and 394 mg/dl, respectively. Serum cholesterol and triglyceride values ranged from 310 to 1251 mg/dl and 107 to 959 mg/dl, respectively. The 1994 total serum cholesterol values ranged from 222 to 1356 mg/dl with a mean of 572 mg/dl. Serum triglyceride values ranged from 134 to 1410 mg/dl with a mean of 423 mg/dl. The 1994 decrease in total serum cholesterol is due to lower concentrations in WHHL rabbits one year and older (406 mg/dl) compared to similarly aged rabbits in 1991 (550 mg/dl).