De-differentiation of committed cells into haematopoietic stem cells by the instructive role of the transcription factor HOXB4

通过转录因子 HOXB4 的指导作用使定型细胞去分化为造血干细胞

• 批准号: nhmrc : 1057812
• 负责人: A/Pr Nicholas Huntington
• 金额: $ 45.55万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/de-differentiation-committed-factor-hoxb4/454633
• 关键词: De; differentiation; committed; cells; into

Blood stem cells are long-lived and can give rise to every cell type of the blood system and due to these properties they are currently used in the clinics. Despite their importance, our knowledge of the mechanisms the control the multiplication of these rare cells is very scarce. This proposal aims to identify key factors that have the potential to convert mature, easy available blood cells into stem cells. This knowledge has to potential to lead to novel system that allow the expansion of stem cells for transplantations in the future.

血液干细胞寿命长，可以产生血液系统的每种细胞类型，由于这些特性，它们目前在诊所中使用。尽管它们很重要，但我们对控制这些稀有细胞增殖的机制的了解非常缺乏。该提案旨在确定有可能将成熟、容易获得的血细胞转化为干细胞的关键因素。这些知识有可能催生出新的系统，允许未来移植干细胞的扩增。