Identification and targeting of a potent NK cell “checkpoint” in tumour immunity
Identification and targeting of a potent NK cell “checkpoint” in tumour immunity
批准号:
nhmrc : GNT1124788
负责人:
A/Pr Nicholas Huntington
金额:
$47.01万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Career Development Fellowships
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --
中文摘要
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英文摘要
Cancer must evade detection by the immune system in order to develop. Natural Killer (NK) cells can detect and kill cancer cells. We have discovered a potent 'checkpoint' in the NK cell activation pathway that desensitizes NK cells to growth factors and switches off their activation and killer function. When this checkpoint is inhibited, NK cells become hyper-activated and prevent most types of cancer metastasis in mice. Targeting this checkpoint in humans could revolutionise cancer therapy
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Identification of CIS as a potent checkpoint in NK cell-mediated tumour immunity
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批准号:nhmrc : 1124784
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项目类别:Project Grants
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资助金额:$65.56万
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财政年份:2017
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负责人:A/Pr Nicholas Huntington
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依托单位:
Identification and targeting of a potent NK cell “checkpoint” in tumour immunity
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批准号:nhmrc : 1124788
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依托单位:
Identification of E-protein complexes controlling natural killer cell fate and tumour immunity
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财政年份:2017
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负责人:A/Pr Nicholas Huntington
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依托单位:
Determining regulators of ILC3 in mucosal barrier function and immune homeostasis
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批准号:nhmrc : 1122277
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项目类别:Project Grants
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资助金额:$48.12万
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财政年份:2017
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负责人:A/Pr Nicholas Huntington
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依托单位:
Identification of CIS as a potent checkpoint in NK cell-mediated tumour immunity
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批准号:nhmrc : GNT1124784
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项目类别:Project Grants
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资助金额:$95.96万
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财政年份:2017
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负责人:A/Pr Nicholas Huntington
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依托单位:
Determining regulators of ILC3 in mucosal barrier function and immune homeostasis
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批准号:nhmrc : GNT1122277
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项目类别:Project Grants
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资助金额:$70.52万
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财政年份:2017
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负责人:A/Pr Nicholas Huntington
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依托单位:
Identification of E-protein complexes controlling natural killer cell fate and tumour immunity
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批准号:nhmrc : GNT1124907
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项目类别:Project Grants
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资助金额:$68.37万
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财政年份:2017
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负责人:A/Pr Nicholas Huntington
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依托单位:
De-differentiation of committed cells into haematopoietic stem cells by the instructive role of the transcription factor HOXB4
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批准号:nhmrc : 1057812
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资助金额:$45.55万
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财政年份:2014
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负责人:A/Pr Nicholas Huntington
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依托单位:
Human xenograft models for haematopoiesis studies
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批准号:nhmrc : 1066770
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项目类别:Project Grants
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资助金额:$44.52万
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依托单位:
Dissecting apoptosis and IL-15 dependent homeostasis pathways of natural killer (NK) cells
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批准号:nhmrc : 1049407
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项目类别:Project Grants
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财政年份:2013
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负责人:A/Pr Nicholas Huntington
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依托单位:
Roles of ID2 in regulating critical innate and adaptive arms of the immune response
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批准号:nhmrc : 1027472
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Natural killer cell development, survival and homeostasis
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财政年份:2007
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负责人:A/Pr Nicholas Huntington
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依托单位:
国内基金
海外基金
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