Identification and targeting of a potent NK cell “checkpoint” in tumour immunity

肿瘤免疫中有效 NK 细胞“检查点”的识别和靶向

• 批准号: nhmrc : 1124788
• 负责人: A/Pr Nicholas Huntington
• 金额: $ 32.12万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-targeting-potent-tumour-immunity/947446
• 关键词: Identification; targeting; potent; NK; cell

Cancer must evade detection by the immune system in order to develop. Natural Killer (NK) cells can detect and kill cancer cells. We have discovered a potent "checkpoint" in the NK cell activation pathway that desensitizes NK cells to growth factors and switches off their activation and killer function. When this checkpoint is inhibited, NK cells become hyper-activated and prevent most types of cancer metastasis in mice. Targeting this checkpoint in humans could revolutionise cancer therapy

癌症必须逃避免疫系统的检测才能发展。自然杀伤（NK）细胞可以检测和杀死癌细胞。我们已经发现了NK细胞活化途径中的一个有效的“检查点”，该检查点使NK细胞对生长因子脱敏并关闭其活化和杀伤功能。当这个检查点被抑制时，NK细胞变得过度活化，并防止小鼠中大多数类型的癌症转移。靶向人类的这一检查点可以彻底改变癌症治疗