Determining regulators of ILC3 in mucosal barrier function and immune homeostasis

确定 ILC3 在粘膜屏障功能和免疫稳态中的调节因子

• 批准号: nhmrc : GNT1122277
• 负责人: A/Pr Nicholas Huntington
• 金额: $ 70.52万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-regulators-ilc3-immune-homeostasis/1347262
• 关键词: Determining; regulators; ILC3; mucosal; barrier

Innate lymphoid cells (ILCs) are specialized cells that defend the body against invading microorganisms at the body’s surfaces, mediate pathogen clearance and tissue repair but may also drive inflammatory conditions such as allergic asthma and inflammatory bowel disease. We will investigate the molecular switches that regulate this novel cell type and potentially uncover novel molecules or pathways for therapeutic targets.

先天淋巴样细胞（ILCs）是一种特殊的细胞，可以保护身体免受身体表面微生物的入侵，介导病原体清除和组织修复，但也可能导致炎症性疾病，如过敏性哮喘和炎症性肠病。我们将研究调节这种新型细胞类型的分子开关，并可能发现治疗靶点的新分子或途径。