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Determining regulators of ILC3 in mucosal barrier function and immune homeostasis

Determining regulators of ILC3 in mucosal barrier function and immune homeostasis
确定 ILC3 在粘膜屏障功能和免疫稳态中的调节因子
批准号：
nhmrc : GNT1122277
负责人：
A/Pr Nicholas Huntington
金额：
$70.52万
依托单位：
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2017
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2017-01-01 至 --
来源：
https://researchdata.edu.au/determining-regulators-ilc3-immune-homeostasis/1347262
关键词：
DeterminingregulatorsILC3mucosalbarrier

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中文摘要
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英文摘要
Innate lymphoid cells (ILCs) are specialized cells that defend the body against invading microorganisms at the body’s surfaces, mediate pathogen clearance and tissue repair but may also drive inflammatory conditions such as allergic asthma and inflammatory bowel disease. We will investigate the molecular switches that regulate this novel cell type and potentially uncover novel molecules or pathways for therapeutic targets.
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Identification of CIS as a potent checkpoint in NK cell-mediated tumour immunity
Identification and targeting of a potent NK cell “checkpoint” in tumour immunity
Identification of E-protein complexes controlling natural killer cell fate and tumour immunity
Determining regulators of ILC3 in mucosal barrier function and immune homeostasis
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