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Human xenograft models for haematopoiesis studies

Human xenograft models for haematopoiesis studies
用于造血研究的人类异种移植模型
批准号:
nhmrc : 1066770
负责人:
A/Pr Nicholas Huntington
金额:
$44.52万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31

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中文摘要
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英文摘要
This research aims to understand the early developmental events in human blood cell diversi?cation that generate cells involved in oxygen transport, wound healing and protecting us from cancer and infection. The ?ndings will assist in diagnosing and treating human immune system and blood cell disorders such as leukaemia, chronic infection and autoimmunity through understanding the mechanisms of how normal, healthy blood cells are generated.
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Identification of CIS as a potent checkpoint in NK cell-mediated tumour immunity
Identification and targeting of a potent NK cell “checkpoint” in tumour immunity
Identification of E-protein complexes controlling natural killer cell fate and tumour immunity
Determining regulators of ILC3 in mucosal barrier function and immune homeostasis
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