Identification of E-protein complexes controlling natural killer cell fate and tumour immunity

控制自然杀伤细胞命运和肿瘤免疫的E蛋白复合物的鉴定

• 批准号: nhmrc : 1124907
• 负责人: A/Pr Nicholas Huntington
• 金额: $ 46.66万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-e-protein-tumour-immunity/947461
• 关键词: Identification; protein; complexes; controlling; natural

Diverse immune cell types are essential for effective broad-spectrum immunity. Master regulators control this diversity and have a well-characterized role in the development of antigen-specific immunity. In contrast, we lack mechanistic understanding of how master regulators control antigen-unspecific, innate immunity. Understanding the mechanism behind this will explain how diverse white blood cells can develop and reveal strategies to skew their development to improve immunity in humans.

多样化的免疫细胞类型对于有效的广谱免疫至关重要。主调节因子控制着这种多样性，并在抗原特异性免疫的发展中具有明确的作用。相比之下，我们对主调节因子如何控制抗原非特异性先天免疫缺乏机制理解。了解其背后的机制将解释多样化的白细胞如何发育，并揭示扭曲其发育以提高人类免疫力的策略。