Identification of E-protein complexes controlling natural killer cell fate and tumour immunity

多样化的免疫细胞类型是有效的广谱免疫所必需的。主调节因子控制这种多样性，并在抗原特异性免疫的发展中具有良好的特征作用。相比之下，我们缺乏对主调节因子如何控制抗原非特异性先天免疫的机制理解。了解这背后的机制将解释不同的白细胞是如何发展的，并揭示扭曲它们的发展以提高人类免疫力的策略。

Diverse immune cell types are essential for effective broad-spectrum immunity. Master regulators control this diversity and have a well-characterized role in the development of antigen-specific immunity. In contrast, we lack mechanistic understanding of how master regulators control antigen-unspecific, innate immunity. Understanding the mechanism behind this will explain how diverse white blood cells can develop and reveal strategies to skew their development to improve immunity in humans.