课题基金 / 基金详情

PICORNAVIRUS-INDUCED CHRONIC INFLAMMATION

PICORNAVIRUS-INDUCED CHRONIC INFLAMMATION
小核糖核酸病毒引起的慢性炎症
批准号：
3819299
负责人：
P H PLOTZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3819299
关键词：
Picornaviridae chronic disease /disorder encephalomyocarditis virus genome inflammation latent virus infection nucleic acid hybridization nucleic acid sequence virus DNA virus RNA virus genetics virus infection mechanism

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中文摘要
翻译
作为慢性炎症发病机制研究的一部分
英文摘要
As part of a study of the pathogenesis of chronic inflammation initiated by a picornavirus, we have tracked the presence of viral genome by in situ hybridization after infection of mice with encephalomyocarditis virus, strain EMC-221A. Viral nucleic acid can be found in cells at least a week or two after disappearance of culturable virus. Inflammation disappears in some organs when virus does, but persists in others for much longer periods. We have worked out a variation of the polymerase chain reaction to detect persistent viral nucleic acid sequences with much higher sensitivity.
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会议论文
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THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES
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