VIRUSES IN THE INDUCTION OF AUTOANTIBODIES IN HUMANS AND MICE

病毒在人和小鼠体内诱导自身抗体

• 批准号: 3961236
• 负责人: P H PLOTZ
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3961236
• 关键词: DNA directed RNA polymerase; Picornaviridae; autoantibody; bacteria; human subject; inflammation; myositis; nutrient interaction; oral health; transfer RNA

Characteristic antibodies which react with normal tissues (autoantibodies) develop in patients with a number of diseases and in some animals. Considerable evidence suggests that some of these antibodies arise because of specific interactions between an exogenous agent (virus, bacterium, drug) and the sites to which the antibody binds. A search is underway to determine whether certain picornaviridiae can be implicated in the causation of inflammatory myositis and the characteristic myositis related antibodies which react with amino acid t-RNA synthetases.

与正常组织发生反应的特异性抗体(自身抗体) 在患有多种疾病的患者和一些动物身上发生。 相当多的证据表明，其中一些抗体的产生是因为 外源病原体(病毒、细菌、 药物)和抗体结合的部位。一项搜索工作正在进行中 确定某些微小导航病毒是否可能牵涉到 炎症性肌炎的病因及与之相关的特征性肌炎 与氨基酸t-RNA合成酶反应的抗体。