ETIOLOGY AND PATHOGENESIS OF IDIOPATHIC INFLAMMATORY MYOPATHY IN HUMANS

人类特发性炎症性肌病的病因和发病机制

• 批准号: 3819298
• 负责人: P H PLOTZ
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3819298
• 关键词: autoantibody; dermatomyositis; disease /disorder classification; human subject; inflammation; polymyositis; serology /serodiagnosis

ldiopathic inflammatory myopathy (poly/dermatomyositis) is an inflammatory disease of muscle in which characteristic autoantibodies occur. By applying a broad range of immunological, clinical, and epidemiological observations to a large (about 150) group of patients, we have developed evidence for subsets of patients which strongly suggest that the disease can be divided into more meaningful groups with different etiology and pathogenesis. So far, the groups of patients with anti-Jo-l antibodies and with antibodies to signal recognition peptide are clinically and epidemiologically as well as serologically distinct from each other and from other patients.

特发性炎症性肌病(息肉/皮肌炎)是一种 肌肉炎症性疾病的哪些特征 会产生自身抗体。通过应用广泛的免疫学方法， 临床和流行病学观察对一个大型(约150人) 一组患者，我们已经发现了亚群的证据 强烈建议这种疾病可以分开的患者 分成更有意义的不同病因和 发病机制。到目前为止，这批抗JO-L的患者 抗体和带有信号识别肽的抗体是 临床和流行病学以及血清学上的不同 从彼此和其他病人那里。