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ETIOLOGY AND PATHOGENESIS OF IDIOPATHIC INFLAMMATORY MYOPATHY IN HUMANS

ETIOLOGY AND PATHOGENESIS OF IDIOPATHIC INFLAMMATORY MYOPATHY IN HUMANS
人类特发性炎症性肌病的病因和发病机制
批准号：
3819298
负责人：
P H PLOTZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3819298
关键词：
autoantibody dermatomyositis disease /disorder classification human subject inflammation polymyositis serology /serodiagnosis

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中文摘要
翻译
特发性炎症性肌病(息肉/皮肌炎)是一种 肌肉炎症性疾病的哪些特征 会产生自身抗体。通过应用广泛的免疫学方法， 临床和流行病学观察对一个大型(约150人) 一组患者，我们已经发现了亚群的证据 强烈建议这种疾病可以分开的患者 分成更有意义的不同病因和 发病机制。到目前为止，这批抗JO-L的患者 抗体和带有信号识别肽的抗体是 临床和流行病学以及血清学上的不同 从彼此和其他病人那里。
英文摘要
ldiopathic inflammatory myopathy (poly/dermatomyositis) is an inflammatory disease of muscle in which characteristic autoantibodies occur. By applying a broad range of immunological, clinical, and epidemiological observations to a large (about 150) group of patients, we have developed evidence for subsets of patients which strongly suggest that the disease can be divided into more meaningful groups with different etiology and pathogenesis. So far, the groups of patients with anti-Jo-l antibodies and with antibodies to signal recognition peptide are clinically and epidemiologically as well as serologically distinct from each other and from other patients.
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会议论文
GENETIC METABOLIC MYOPATHIES--PHOSPHOFRUCTOKINASE/ACID MALTASE DEFICIENCY
IMMUNOPATHOGEN AUTOIMMUNE INFLAMMATORY MYOPATHIES--POLYMYOSITIS/DERMATOMYOSITIS
THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES
VIRUSES IN THE INDUCTION OF AUTOANTIBODIES IN HUMANS AND MICE
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