THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES

特发性炎症性肌病的治疗试验

• 批准号: 3804556
• 负责人: P H PLOTZ
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3804556
• 关键词: azathioprine; clinical trials; combination chemotherapy; cyclophosphamide; dermatomyositis; drug administration rate /duration; human subject; human therapy evaluation; inflammation; intravenous administration; leucovorin; leukapheresis; methotrexate; muscle disorder chemotherapy; plasmapheresis; polymyositis

Severe idiopathic inflammatory myopathies (polymyositis, dermatomyositis, and related diseases) that respond poorly to corticosteroids are difficult to treat. We have undertaken three therapeutic trials for the treatment of such patients: a) a controlled double-blind trial of phasmapheresis and leukapheresis; b) a controlled, crossover trial of intravenous methotrexate with leucovorin rescue and combination of methotrexate and azathioprine; c) an open trial of i.v. cyclophosphamide (completed). The trial of apheresis has just been closed after 39 patients have completed it. Analysis of the results is underway. The trial of i.v. methotrexate and combination therapy continues, although patients with inclusion body myositis are no longer being entered because of poor results in the first 12 patients randomized.

严重的特发性炎性肌病（多发性肌炎， 皮肌炎和相关疾病）， 皮质类固醇很难治疗。我们已经进行了三次 用于治疗此类患者的治疗性试验：a）对照试验， 相位去除法和白细胞去除法的双盲试验; B）对照， 静脉注射甲氨蝶呤与甲酰四氢叶酸的交叉试验 甲氨蝶呤和硫唑嘌呤的组合; c）i. v. 环磷酰胺（完成）。 在39名患者接受了 已完成，有关结果的分析正在进行中。 静脉注射试验 甲氨蝶呤和联合治疗仍在继续，尽管 包涵体肌炎不再被输入，因为穷人 前12名随机化患者的结果。