THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES

一项双盲、随机、对照的治疗试验分析 分离术在多发性肌炎或皮肌炎治疗中的应用 完成。无论是血浆置换还是淋巴清扫都不会带来更好的 结果比虚假的手术要好。 试图找到治疗类固醇抗药性肌炎的更好方法 (除包涵体肌炎外)，我们已经进行了随机 静脉注射甲氨蝶呤与解救白血球蛋白的交叉试验 甲氨蝶呤和硫唑嘌呤的组合。病人的应计费用是 大约完成了三分之二。 我们对这种疗法进行了两次广泛的回顾分析。 肌炎的症状。一，超过100名患者的详细记录 回答是可用的，被分析为影响因素 对强的松、甲氨蝶呤和硫唑嘌呤的反应。另一个 对类固醇和细胞毒治疗的反应进行了仔细的分析 在近30名包涵体肌炎患者中，包括 首次对照治疗试验的分析 我们在过去几年里实施的条件。

Analysis of a double-blind, randomized, controlled therapeutic trial of apheresis in the treatment of polymyositis or dermatomyositis was completed. Neither plasmapheresis nor lymphapheresis led to a better outcome than a sham procedure. In an attempt to find a better way to treat steroid-resistant myositis (other than inclusion body myositis), we have carried out a randomized crossover trial of intravenous methotrexate with leukovorin rescue and a combination of methotrexate and azathioprine. Accrual of patients is about two-thirds complete. We have carried out two extensive retrospective analyses of the therapy of myositis. One, well over 100 patients on whom thorough records of responses were available, was analyzed for the factors that influence the responses to prednisone, methotrexate, and azathioprine. The other was a close analysis of the responses to steroid and cytotoxic therapy in almost 30 patients with inclusion body myositis, including an analysis of the first ever controlled therapeutic trial in that condition which we carried out over the past several years.