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THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES

THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES
特发性炎症性肌病的治疗试验
批准号：
3810931
负责人：
P H PLOTZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3810931
关键词：
azathioprine combination chemotherapy cyclophosphamide dermatomyositis drug administration rate /duration drug administration routes human subject human therapy evaluation inflammation leucovorin leukapheresis methotrexate muscle disorder chemotherapy plasmapheresis polymyositis

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中文摘要
翻译
严重的特发性炎性肌病(多发性肌炎、皮肌炎、
英文摘要
Severe idiopathic inflammatory myopathies (polymyositis, dermatomyositis, and related diseases) that respond poorly to corticosteroids are difficult to treat. We have undertaken three therapeutic trials for the treatment of such patients: a) a controlled double-blind trial of phasmapheresis and leukapheresis; b) a controlled, crossover trial of intravenous methotrexate with leucovorin rescue and a combination of methotrexate and azathioprine; c) an open trial of i.v. cyclophosphamide (completed). The trial of apheresis has just been closed after 39 patients have completed it. Analysis of the results is underway. The trial of i.v. methotrexate and combination therapy continues, although patients with inclusion body myositis are no longer being entered because of poor results in the first 12 patients randomized.
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会议论文
GENETIC METABOLIC MYOPATHIES--PHOSPHOFRUCTOKINASE/ACID MALTASE DEFICIENCY
IMMUNOPATHOGEN AUTOIMMUNE INFLAMMATORY MYOPATHIES--POLYMYOSITIS/DERMATOMYOSITIS
THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES
VIRUSES IN THE INDUCTION OF AUTOANTIBODIES IN HUMANS AND MICE
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