RENAL BIOPSY PATHOLOGY IN SYSTEMIC LUPUS ERYTHEMATOSUS

多种致病因素在系统性红斑狼疮中的作用 并导致不同形式的狼疮性肾炎。详细分析了 正在对患者的样本进行肾活检病理检查。 系统性红斑狼疮。 活检按狼疮性肾炎的标准主要类别进行分类， 以及对特定组织学的半定量评分 表明活动性炎症的程度和严重程度的变化 病变有慢性萎缩性、纤维化性和硬化性特征。这个 免疫复合体沉积模式和淋巴样细胞与 肾单位的不同节段正在接受调查 免疫组织学技术和电子显微镜。 这些方法有助于分析各种不同的 用于阻止狼疮进展的免疫抑制剂的种类 它们将加深我们对肾炎发病机制的理解 狼疮性肾炎。

Diverse pathogenetic factors are operant in systemic lupus erythematosus and lead to different forms of lupus nephritis. Detailed analysis of renal biopsy pathology is being conducted on specimens from patients with systemic lupus erythematosus. Biopsies are classified by standard major category of lupus nephritis, as well as scored on a semi-quantitative scale for specific histologic changes which indicates the extent and severity of active inflammatory lesions and chronic atrophic, fibrosing and sclerosing features. The patterns of immune complex deposition and lymphoid cell interaction with different segments of the nephron are being investigated by immunohistologic techniques and electron microscopy. These approaches have facilitated the analysis of the effects of various types of immunosuppressive agents used to halt the progression of lupus nephritis and they will enhance our understanding of the pathogenesis of lupus nephritis.