RENAL BIOPSY PATHOLOGY IN SYSTEMIC LUPUS ERYTHEMATOSUS

系统性红斑狼疮的发病因素多种多样 并导致不同形式的狼疮性肾炎。详细分析 正在对患者标本进行肾活检病理学检查 患有系统性红斑狼疮。 活检按狼疮性肾炎的标准主要类别进行分类， 以及针对特定组织学的半定量评分 表明活动性炎症的程度和严重程度的变化 病变和慢性萎缩、纤维化和硬化特征。的 免疫复合物沉积和淋巴细胞相互作用的模式 正在研究肾单位的不同部分 免疫组织学技术和电子显微镜。 这些方法有助于分析各种因素的影响 用于阻止狼疮进展的免疫抑制剂类型 肾炎，它们将增强我们对肾炎发病机制的了解 狼疮性肾炎。

Diverse pathogenetic factors are operant in systemic lupus erythematosus and lead to different forms of lupus nephritis. Detailed analysis of renal biopsy pathology is being conducted on specimens from patients with systemic lupus erythematosus. Biopsies are classified by standard major category of lupus nephritis, as well as scored on a semi-quantitative scale for specific histologic changes which indicates the extent and severity of active inflammatory lesions and chronic atrophic, fibrosing and sclerosing features. The patterns of immune complex deposition and lymphoid cell interaction with different segments of the nephron are being investigated by immunohistologic techniques and electron microscopy. These approaches have facilitated the analysis of the effects of various types of immunosuppressive agents used to halt the progression of lupus nephritis and they will enhance our understanding of the pathogenesis of lupus nephritis.