RENAL BIOPSY PATHOLOGY IN SYSTEMIC LUPUS ERYTHEMATOSUS

系统性红斑狼疮的肾活检病理学

• 批准号: 3840295
• 负责人: J E BALOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3840295
• 关键词: biopsy; child (0-11); disease /disorder classification; electron microscopy; histopathology; human subject; human tissue; immunocytochemistry; immunosuppressive; lymphocyte; nephritis; pathologic process; systemic lupus erythematosus

Diverse pathogenetic factors are operant in systemic lupus erythematosus and lead to different forms of lupus nephritis. Detailed analysis of renal biopsy pathology is being conducted on specimens from patients with systemic lupus erythematosus. Biopsies are classified by standard major category of lupus nephritis, as well as scored on a semi-quantitative scale for specific histologic changes which indicates the extent and severity of active inflammatory lesions and chronic atrophic, fibrosing and sclerosing features. The patterns of immune complex deposition and lymphoid cell interaction with different segments of the nephron are being investigated by immunohistologic techniques and electron microscopy. These approaches have facilitated the analysis of the effects of various types of immunosuppressive agents used to halt the progression of lupus nephritis and they will enhance our understanding of the pathogenesis of lupus nephritis.

系统性红斑狼疮的发病因素多种多样 并导致不同形式的狼疮性肾炎。仔细的分析 对患者的标本进行肾活检病理学检查 系统性红斑狼疮 活组织检查按狼疮性肾炎的标准主要类别分类， 以及在特定组织学的半定量量表上评分， 指示活动性炎症的程度和严重性的变化 病变和慢性萎缩、纤维化和硬化特征。的 免疫复合物沉积模式和淋巴细胞与 肾单位的不同部分正在被研究， 免疫组织学技术和电子显微镜。 这些方法有助于分析各种因素的影响， 用于阻止狼疮进展的免疫抑制剂类型 肾炎，他们将提高我们对发病机制的认识， 狼疮性肾炎