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IMMUNOSUPPRESSION AND PLASMAPHERESIS IN GOODPASTURE'S SYNDROME

IMMUNOSUPPRESSION AND PLASMAPHERESIS IN GOODPASTURE'S SYNDROME
Goodpasture 综合征中的免疫抑制和血浆去除术
批准号：
4689968
负责人：
J E BALOW
金额：
$0.0万
依托单位：
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4689968
关键词：
Goodpasture's syndrome autoantibody autoimmune disorder drug adverse effect glomerulonephritis human subject human therapy evaluation immunopathology chemotherapy immunosuppression immunosuppressive plasmapheresis

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英文摘要
Goodpasture's Syndrome is usually characterized by rapidly progressive glomerulonephritis due to autoantibodies against glomerular basement membrane (anti-GBM). This study will examine whether plasmapheresis significantly improves the results of standard immunosuppressive drug treatment of this disease. Patients will be randomly allocated to drug treatment alone or drugs plus plasmapheresis until anti-GBM levels are undetectable. Comparison will be made of the numbers of favorable outcomes and complication rates of these therapies at the end of 6 months of study. Analysis of the balance of efficacy, complications and expense of plasmapheresis in treatment of Goodpasture's syndrome will be facilitated by the results of this study.
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