RENAL BIOPSY PATHOLOGY IN SYSTEMIC LUPUS ERYTHEMATOSUS

系统性红斑狼疮的肾活检病理学

• 批准号: 4689970
• 负责人: J E BALOW
• 金额: --
• 依托单位: NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4689970
• 关键词: biopsy; electron microscopy; human subject; human tissue; immune complex; immunochemistry; immunosuppressive; kidney; lymphocyte; nephritis; nephrosclerosis; pathologic process; renal tubule; systemic lupus erythematosus

The pathogenetic mechanisms underlying the different forms of lupus nephritis are being investigated. Detailed analysis of renal biopsy pathology is being conducted on specimens from patients with systemic lupus erythematosus. Biopsies are classified by major category of lupus nephritis, as well as scored on a semiquantitative scale for specific histologic changes indicating the degree of activity and of chronic sclerosing features. The patterns of immune complex deposition and lymphoid cell interaction with different segments of the nephron are being investigated by immunohistologic techniques and electron microscopy. These approaches have facilitated the analysis of the effects of various types of immunosuppressive agents used to halt the progression of lupus nephritis and they will enhance our understanding of the pathogenesis of this disease.

不同形式狼疮的发病机制 正在研究肾炎。 肾活检详细分析 对系统性狼疮患者的标本进行病理学检查 红斑 活检是根据狼疮的主要类别分类的 肾炎，以及在特定的半定量量表上评分 组织学变化表明活动程度和慢性 硬化特征。 免疫复合物沉积的模式和 淋巴样细胞与肾单位不同部分的相互作用 通过免疫组织学技术和电子显微镜进行研究。 这些 各种方法有助于分析各种类型的 狼疮性肾炎的治疗方法有哪些 他们将增强我们对这种疾病的发病机制的理解， 疾病