RENAL BIOPSY PATHOLOGY IN SYSTEMIC LUPUS ERYTHEMATOSUS

系统性红斑狼疮的肾活检病理学

• 批准号: 3918202
• 负责人: J E BALOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918202
• 关键词: biopsy; child (0-11); drug adverse effect; electron microscopy; histopathology; human subject; immune complex; immunochemistry; immunosuppressive; kidney; nephritis; nephrosclerosis; pathologic process; renal tubule; systemic lupus erythematosus

The pathogenetic mechanisms underlying the different forms of lupus nephritis are being investigated. Detailed analysis of renal biopsy pathology is being conducted on specimens from patients with systemic lupus erythematosus. Biopsies are classified by major category of lupus nephritis, as well as scored on a semiquantitative scale for specific histologic changes indicating the degree of activity and of chronic sclerosing features. The patterns of immune complex deposition and lymphoid cell interaction with different segments of the nephron are being investigated by immunohistologic techniques and electron microscopy. Morphometric techniques are being developed to analyze more precisely the changes in renal pathology during the course of lupus nephritis. These approaches have facilitated the analysis of the effects of various types of immunosuppressive agents used to halt the progression of lupus nephritis and they will enhance our understanding of the pathogenesis of this disease.

不同形式狼疮的发病机制 正在研究肾炎。 肾功能的详细分析 活检病理学正在对来自患有以下疾病的患者的标本进行 系统性红斑狼疮 活检按主要分类 狼疮性肾炎的分类，以及评分 特定组织学变化的半定量量表， 活动程度和慢性硬化特征。 的 免疫复合物沉积和淋巴细胞相互作用的模式 与肾单位不同部分的关系正在被研究， 免疫组织学技术和电子显微镜。 形态测定 技术正在发展，以更精确地分析 狼疮性肾炎的早期症状有哪些？ 这些方法有助于分析 各种类型的免疫抑制剂用于阻止 狼疮性肾炎的进展，他们将提高我们的 了解这种疾病的发病机制。