RENAL BIOPSY PATHOLOGY IN SYSTEMIC LUPUS ERYTHEMATOSUS

多种致病因素在系统性红斑狼疮中的作用 并导致不同形式的狼疮性肾炎。肾脏的详细分析 活组织病理检查正在对来自以下患者的样本进行 系统性红斑狼疮。 活组织检查按狼疮性肾炎的标准主要类别分类，如 并对特定的组织学改变进行半定量评分 表明活动性炎性病变的范围和严重程度 慢性萎缩性、纤维化和硬化性特征。的模式。 免疫复合体沉积与淋巴细胞相互作用的研究 肾单位的节段正在进行免疫组织学研究。 技术和电子显微镜。基于计算机的形态测量技术 正在被开发来更精确地分析肾脏的变化 狼疮性肾炎病程中的病理变化。 这些方法有助于分析各种不同的 用于阻止狼疮进展的免疫抑制剂的种类 它们将加深我们对肾炎发病机制的理解 系统性红斑狼疮的肾脏疾病。

Diverse pathogenetic factors are operant in systemic lupus erythematosus and lead to different forms of lupus nephritis. Detailed analysis of renal biopsy pathology is being conducted on specimens from patients with systemic lupus erythematosus. Biopsies are classified by standard major category of lupus nephritis, as well as scored on a semiquantitative scale for specific histologic changes which indicates the extent and severity of active inflammatory lesions and of chronic atrophic, fibrosing and sclerosing features. The patterns of immune complex deposition and lymphoid cell interaction with different segments of the nephron are being investigated by immunohistologic techniques and electron microscopy. Computer-based morphometric techniques are being developed to analyze more precisely the changes in renal pathology during the course of lupus nephritis. These approaches have facilitated the analysis of the effects of various types of immunosuppressive agents used to halt the progression of lupus nephritis and they will enhance our understanding of the pathogenesis of the kidney disease of systemic lupus erythematosus.