DISORDERS OF IMMUNE REGULATION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

系统性红斑狼疮患者的免疫调节紊乱

• 批准号: 3964765
• 负责人: J E BALOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3964765
• 关键词: B lymphocyte; T lymphocyte; corticosteroids; cyclophosphamide; human subject; immunopathology; immunosuppressive; lymphokines; systemic lupus erythematosus

Patients with systemic lupus erythematosus have been found to have various disturbances of the cell-mediated immune response. Cellular aberrations include enhanced spontaneous B cell activity with abnormal triggering in vitro, deficient immunoregulatory T cell circuits, deficient cytotoxic responses, including natural killer cell activity, alloantigen and viral cytotoxicity, and finally abnormal production of and response to different lymphokines. The goal of these studies is to further elucidate the mechanisms of these alterations of the immune system which are apparently involved in the pathogenesis of this disease. The modulation of the above disturbances by immunosuppressive agents, i.e. corticosteroids and cyclophosphamide, is actively studied, aiming at the restoration of normal immune status in these patients.

已经发现系统性红斑狼疮患者具有各种 细胞介导的免疫反应的紊乱。 细胞畸变 包括增强自发B细胞活性， 体外，免疫调节性T细胞回路缺陷，细胞毒性 包括自然杀伤细胞活性、同种异体抗原和病毒 细胞毒性，最后异常产生和反应， 淋巴因子 这些研究的目的是进一步阐明 这些免疫系统改变的机制， 参与了这种疾病的发病机制。 上述调制 免疫抑制剂，即皮质类固醇和 环磷酰胺，正在积极研究，旨在恢复正常 这些患者的免疫状态。