DETECTION OF DRUGS OF ABUSE IN HUMAN SALIVA

人类唾液中滥用药物的检测

• 批准号: 3838564
• 负责人: E J CONE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838564
• 关键词: blood chemistry; cocaine; diagnosis design /evaluation; diagnosis quality /standard; drug abuse; drug detection; gas chromatography mass spectrometry; human subject; male; marijuana abuse; noninvasive diagnosis; opiate alkaloid; psychophysiology; radioimmunoassay; saliva

The presence of drugs of abuse in saliva of human subjects after drug administration was studied to determine the feasibility of drug testing with saliva. Healthy male subjects with a history of chemical substance abuse volunteered for the studies. Informed consent was obtained and all procedures were approved by the hospital Institutional Review Board. Following the administration of cocaine, marijuana or opiate, saliva and blood samples were collected periodically. Behavioral and physiological measures were made concurrently with collection of biological fluids. Samples were analyzed by RIA and gas chromatography/mass spectrometry. Significant correlation's of blood levels with saliva levels were found for cocaine and opiates. These studies provide the scientific basis for development of new non-invasive saliva tests for drugs of abuse.

药物滥用后人类受试者唾液中药物的存在 管理进行了研究，以确定药物测试的可行性 唾液。 有化学物质史的健康男性受试者 志愿参加了研究。 获得了知情同意书，所有 该程序由医院机构审查委员会批准。 在服用可卡因、大麻或鸦片制剂后，唾液和 定期采集血样。 行为和生理 在收集生物液体的同时进行测量。 采用RIA和气相色谱/质谱法对样品进行分析。 血液水平与唾液水平的显着相关性被发现， 可卡因和鸦片 这些研究为开发新的 非侵入性唾液测试药物滥用