DETECTION OF DRUGS OF ABUSE IN HUMAN SALIVA

人体服药后唾液中是否存在滥用药物 对药物管理进行了研究以确定药物测试的可行性 用唾液。有化学物质史的健康男性受试者 艾布拉姆斯自愿参加了这些研究。已获得知情同意，所有 程序得到了医院机构审查委员会的批准。 在服用可卡因、大麻或鸦片后，唾液和 定期采集血样。行为和生理 在采集生物液的同时采取了措施。 样品用放射免疫法和气相色谱/质谱仪进行分析。 血液水平和唾液水平之间存在显著的相关性 可卡因和鸦片类药物。 这些研究为新能源的开发提供了科学依据。 滥用药物的非侵入性唾液测试。

The presence of drugs of abuse in saliva of human subjects after drug administration was studied to determine the feasibility of drug testing with saliva. Healthy male subjects with a history of chemical substance abuse volunteered for the studies. Informed consent was obtained and all procedures were approved by the hospital Institutional Review Board. Following the administration of cocaine, marijuana or opiate, saliva and blood samples were collected periodically. Behavioral and physiological measures were made concurrently with collection of biological fluids. Samples were analyzed by RIA and gas chromatography/mass spectrometry. Significant correlation's of blood levels with saliva levels were found for cocaine and opiates. These studies provide the scientific basis for development of new non-invasive saliva tests for drugs of abuse.