ORAL PHYSIOLOGY OF AGING

衰老的口腔生理学

• 批准号: 3839290
• 负责人: A KINGMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3839290
• 关键词: aging; biomarker; dental alveolus; dental disorder diagnosis; dental research; diagnosis design /evaluation; early diagnosis; epidemiology; oral health; pathologic bone resorption

The oral research component of the Baltimore Longitudinal Study of Aging (BLSA), since its inception in 1978, has been designed to evaluate the physiological and pathological factors that influence the oral health and function of individuals of different ages. Currently, the EODPP, is developing plans to broaden the scope of research to include studies of alveolar bone loss in the oral cavity, the detection and application of oral molecular biological markers for systemic disease, and an expanded periodontal evaluation implementing protein markers and DNA microbial probes for early disease detection. The oral epidemiology component is also working with the BLSA to increase minority enrollment thereby increasing the diversity of the BLSA population base. The implementation of these additional areas of investigation within the BLSA, present an opportunity to enhance the overall understanding of age related changes in the oral cavity.

巴尔的摩老龄化纵向研究的口腔研究部分 （BLSA）自1978年成立以来，一直旨在评估 影响口腔健康的生理和病理因素 不同年龄段的个体的功能。 目前，EODPP是 制定计划，扩大研究范围， 口腔牙槽骨丢失的检测及应用 系统性疾病的口服分子生物学标志物，以及一种扩展的 牙周评估实施蛋白质标记物和DNA微生物 用于早期疾病检测的探针。口腔流行病学部分是 还与BLSA合作，以增加少数民族的入学率， 增加BLSA人口基础的多样性。执行 在BLSA内的这些额外调查领域中， 有机会提高对年龄相关变化的整体认识 在口腔中。