ARTERIAL KINETICS OF SMOKED COCAINE

本研究的受试者测试已完成。 初步分析 数据显示通过快速静脉注射给予可卡因 (10秒）或吸入烟雾（“裂纹”）产生高度 在动脉循环中的药物的集中波或团， 至少是静脉循环中的10倍。 其他手段 可卡因滥用不会产生如此高的动脉药物 程度. 这团药在30秒内达到峰值，并迅速消散 在几分钟内，对应于药物对 心血管和主观参数。 这些数据显示， 心脏和大脑的一侧暴露于可卡因浓度 几分钟，远远超过了以前的时间， 假设发生。 正在进行的数据分析将有助于确定 两种途径的动力学在性质上或数量上不同， 然而，这些初步分析表明， 基础可卡因蒸气或具有相同（如果不是更大）的生理潜力 造成伤害和成瘾的快速静脉注射。

Subject testing on this study was completed. Preliminary analysis of the data showed that administration of cocaine by rapid intravenous injection (10 seconds) or by smoke inhalation ("crack") produces a highly concentrated wave or bolus of drug in the arterial circulation which is at least 10 times greater than occurs in venous circulation. Other means of cocaine abuse would not be expected to produce such high arterial drug levels. This bolus peaks within 30 seconds, and rapidly dissipates within a few minutes, corresponding to the peak impact of drug on cardiovascular and subjective parameters. These data show that the left side of the heart and the brain are exposed to concentrations of cocaine for a few minutes that are far in excess these of what was previously assumed to occur. Ongoing data analyses will help determine if the kinetics of the two routes differ either qualitatively or quantitatively, however, these preliminary analyses indicate that the inhalation of free base cocaine vapor or has the same, if not greater, physiologic potential to harm and addict as rapid intravenous injections.