FACTORS INFLUENCING BEHAVIORAL AND PHYSIOLOGIC RESPONSE TO OPIOIDS

根据观察，吸毒者和非阿片类药物使用者 对阿片类药物有不同的敏感性，甚至可能会有反应 性质上的不同，以及这种差异的可能性 或者使某些人容易滥用阿片类药物和/或促成 复发，这项研究是为了从实验上检验这种 U和kappa阿片类药物反应的种群差异。突出 衡量标准包括行为影响的辨别阈值， 生理反应和神经内分泌反应。后成瘾者和 阿片类药物幼稚的受试者打算单独进行测试 比较一下。涉及戒毒后志愿者的初始阶段测试是 然而，完成后，优先事项的变化导致终止 对阿片类药物幼稚受试者之前的方案进行测试。

Following from the observations that post-addicts and non-opioid users are differentially sensitive to opioids, and perhaps even respond qualitatively differently, and the possibility that such differences either predispose certain persons to opioid abuse and/or contribute to relapse, this study was conducted to experimentally examine such population differences in response to mu and kappa opioids. Prominent measures included discrimination thresholds of behavioral effects, physiologic responses, and neuroendocrine response. Post-addict and opioid-naive subjects were intended to be separately tested for comparison. Initial phase testing involving post-addict volunteers was completed, however, changes in priorities resulted in the termintion of the protocol before opioid-naive subjects were tested.