INTERACTION BETWEEN ETHANOL AND PROSTAGLANDIN SYNTHETASE INHIBITORS

对有适度饮酒史的受试者进行研究 住宅研究单位将评估乙醇的影响 不使用对乙酰氨基酚(325、650、1300和1950 mg)或 安慰剂。对乙酰氨基酚是一种前列腺素合成酶抑制剂，具有 已被证明可以减少几种行为和生理影响 酒精在动物研究中，酒精的部分作用似乎是通过增加 前列腺素水平。这项药物相互作用研究利用了我们的 评估滥用潜力和性能的标准程序 评估在人类受试者中产生这种对抗效应的可能性。 这项研究是与临床前分部合作进行的。 受试者测试已经完成。初步分析表明， 这个剂量的酒精(0.625克/公斤，服用超过90分钟)会引起 主观效果(醉酒、感觉吸毒、清醒等)，但不可靠 改变生理或表现指标。用来进行前处理 对乙酰氨基酚不影响主观效果。结果是 已提交供出版。

Subjects with histories of moderate alcohol use are studied on the Residential Research Unit to assess the effects of ethanol following pretreatment with neither acetaminophen (325, 650, 1300 and 1950 mg) or placebo. Acetaminophen is a prostaglandin synthetase inhibitor that has been shown to reduce several behavioral and physiologic effects of alcohol in animal studies, alcohol appears to act in part by increasing prostaglandin levels. This drug interaction study makes use of our standard procedures for assessing abuse potential and performance to evalate the possibility of such antagonistic effects in human subjects. This study is conducted in collaboration with the Preclinical Branch. Subject testing has been completed. Preliminary analyses indicate that alcohol at this dosage (0.625 gm/kg, taken over 90 mins) caused subjective effects (drunk, feel drug, sober, etc) but did not reliably change physiologic or performance measures. Pretreatment with acetaminophen did not influence the subjective effects. The results are submitted for publication.