BEHAVIORAL/PHARMACOLOGIC FACTORS IN NICOTINE REPLACEMENT FOR TOBACCO DEPENDENCE

尼古丁Polacrilex(口香糖)一直作为一种 替代烟草传递的尼古丁，也是一种方便的药物 提供更广泛关注的模式的管理模式 对药物依赖研究人员来说。尼古丁的有效实施 临床环境中的替代策略需要进行 评估各种参数的基础研究，如剂量和 依赖性的测量。在过去的一年里，我们检查了时间 尼古丁在口腔粘膜中的吸收过程 在我们评估的第二项研究中，Polacrilex(口香糖)的使用。初步分析 口服动力学研究表明，大量的尼古丁 通过口腔粘膜吸收在咀嚼后30秒内发生。 对可能存在的种族差异的研究的初步分析表明 对牛奶不耐受的人(即许多非洲人 和亚洲传统)会导致呼出的空气中CO水平升高。

Nicotine polacrilex (chewing gum) has been under investigation as a replacement for tobacco-delivered nicotine and also as a convenient drug administration modality which provides a model of more general interest for drug dependence researchers. Effective implementation of nicotine replacement strategies in clinical settings has required the conduct of basic research to evaluate various parameters such as dosing and measurement of dependence. During the past year we examined the time course of absorption of nicotine in the oral mucosa following nicotine polacrilex (gum) use in a second study we assessed. Preliminary analyses of the oral kinetics study suggest that substantial levels of nicotine absorption via the oral mucosa occur within 30 seconds of chewing. Preliminary analyses of the study of possible ethnic differences suggest that persons who are intolerant to milk (i.e., many persons of African and Asian heritage) yield elevated expired air CO levels.