EFFECTS OF NICOTINE IN NONSMOKERS

非吸烟者接触到的尼古丁是以尼古丁的形式存在的 polacrilex胶;初步试验表明，该制剂 低滥用倾向，如果按照规定给予， 程序. 两个重要的实验问题是解决这一点 study. 一个是关于尼古丁作用的进一步评估 polacrilex口香糖在非吸烟者，以确定可能的影响， 在不存在预先存在的尼古丁的情况下，尼古丁对认知性能的影响 依赖 尼古丁增强了剥夺吸烟者的表现;然而， 尼古丁依赖是否是一个先决条件还有待确定， 这种效果。 第二个问题是普遍重要的， 了解药物依赖的发展。 使用一个模型， 每日重复自愿累积给药，疗程可能 发展对主观、行为和生理 将确定尼古丁的作用。这些数据不能轻易地 与其他药物滥用，可能不是与形式的 已知具有高滥用倾向的尼古丁（例如，香烟），但可能 按照本研究中使用的程序安全采集。 主题 测试已完成（n=12），目前正在分析数据。 初步结果表明，尼古丁并没有提高任务， 性能和对尼古丁影响的耐受性， 一些措施，但不是全部措施。数据的初步报告是 1990年药物管制问题委员会会议上提出的报告 1991年的会议上将提出一份更全面的报告。 美国心理学会。

Nonsmokers are exposed to nicotine given in the form of nicotine polacrilex gum; preliminary testing suggests that this formulation is of low abuse liability and is safe if given according to prescribed procedures. Two important experimental questions are addresed in this study. One concerns the further evaluation of the effects of nicotine polacrilex gum in nonsmokers to determine the possible effects of nicotine on cognitive performance in the absence of pre-existing nicotine dependence. Nicotine enhances performance in deprived smokers; however, it remains to be determined if nicotine dependence is a precondition for this effect. The second question is of general importance to the understanding of the development of drug dependence. Using a model of daily repeated voluntary cumulative dosing, the course of possible development of tolerance to the subjective, behavioral and physiologic actions of nicotine will be determined. Such data cannot be readily obtained with other drugs of abuse, and probably not with forms of nicotine known to be of high abuse liability (e.g., cigarettes), but may be safely collected following the procedures used in this study. Subject testing is completed (n=12) and data are currently being analyzed. Preliminary results indicate that nicotine did not enhance task performance and that tolerance to the effects of nicotine developed for some, but not all, measures. A preliminary report of the data was presented at the 1990 meeting of the Committee on Problems of Drug Dependence and a more complete report will be made at the 1991 meeting of the American Psychological Association.