EFFECTS OF DRUGS ON CIGARETTE SMOKING AND RESPONSES TO NICOTINE

最初的研究是在 约翰霍普金斯大学行为药理学研究中心 学校与Dr. R.格里菲斯提供了一些 研究支持。 例如，吸烟的多种措施， 在AD期间收集主观效应和生理效应 在正常志愿者中， 美加明纳洛酮或大麻 目前，正在收集吸烟的基本措施， 临床研究单位的所有受试者和数据分析已经开始。 这种数据库类型的研究似乎提供了机会， 量化各种变量对吸烟的影响 (i.e.,阿托品给药、可卡因戒断、丁丙诺啡 被动吸烟（passive tobacco smoke）。

Initial studies were conducted in the physical facilities of the Behavioral Pharmacology Research Unit at Johns Hopkins University medical School in collaboration with Dr. R.R. Griffith which provided some research support. For example, multiple measures of cigarette smoking, subjective effect, and physiologic effect were collected during ad libitum smoking sessions in normal volunteers following administration of mecamylamine, naloxone, or marijuana. Presently, basic measures of cigarette smoking are being collected from all subjects on the Clinical Research Unit and data analyses have begun. This database-type of study appears to be providing the opportunity to quantitate the effects of a wide range of variables on cigarette smoking (i.e., atropine administration, cocaine withdrawal, buprenorphine administration, and passive tobacco smoke exposure).