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BACTERIOPHAGE T4 ANTIMUTATOR MUTATIONS

BACTERIOPHAGE T4 ANTIMUTATOR MUTATIONS
噬菌体 T4 抗突变剂突变
批准号：
3841138
负责人：
J W DRAKE
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3841138
关键词：
DNA directed DNA polymerase bacterial genetics bacteriophage T4 biochemical evolution gene mutation nucleic acid sequence

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中文摘要
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英文摘要
Mutations in the bacteriophage T4 DNA polymerase gene sometimes reduce spontaneous mutation rates, in which case they have been called antimutator mutations. It has gradually become clear that while some kinds of mutations are reduced in frequency in such strains, other kinds of mutations are increased. Both structural and evolutionary considerations suggested that a decrease in the total mutation rate is unlikely to be achievable by a single missense mutation except perhaps at the cost of a reduced rate of DNA synthesis. The average mutation rate over a target of roughly 5 kilobase pairs was determined in a set of 12 antimutator mutations. In each case, the rate was indistinguishable from or greater than the wild-type mutation rate.
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会议论文
ROLE OF GENE UVSW IN ERROR-PRONE REPAIR BY BACTERIOPHAGE T4
DNA SEQUENCE CHARACTERIZATION OF BACTERIOPHAGE T4 RII MUTATIONS
ERROR-PRONE REPAIR IN BACTERIOPHAGE T4
ROLE OF GENE UVSX IN ERROR-PRONE REPAIR BY BACTERIOPHAGE T4
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