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BACTERIOPHAGE T4 ANTIMUTATOR MUTATIONS

BACTERIOPHAGE T4 ANTIMUTATOR MUTATIONS
噬菌体 T4 抗突变剂突变
批准号：
3841138
负责人：
J W DRAKE
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3841138
关键词：
DNA directed DNA polymerase bacterial genetics bacteriophage T4 biochemical evolution gene mutation nucleic acid sequence

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中文摘要
翻译
噬菌体T4 DNA聚合酶基因的突变有时会降低 自发突变率，在这种情况下，它们被称为抗突变剂 突变。 人们逐渐清楚，虽然某些类型的 在这些菌株中突变的频率降低，其他种类的 突变增加了。 结构和进化的考虑 这表明，总突变率的下降是不太可能的。 可以通过一个单一的错义突变，除非可能是在一个成本， 降低DNA合成速率。 平均突变率超过一个目标 在一组12个抗突变体中，确定了大约5个酶对 突变。 在每种情况下， 比野生型的突变率高。
英文摘要
Mutations in the bacteriophage T4 DNA polymerase gene sometimes reduce spontaneous mutation rates, in which case they have been called antimutator mutations. It has gradually become clear that while some kinds of mutations are reduced in frequency in such strains, other kinds of mutations are increased. Both structural and evolutionary considerations suggested that a decrease in the total mutation rate is unlikely to be achievable by a single missense mutation except perhaps at the cost of a reduced rate of DNA synthesis. The average mutation rate over a target of roughly 5 kilobase pairs was determined in a set of 12 antimutator mutations. In each case, the rate was indistinguishable from or greater than the wild-type mutation rate.
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会议论文
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