NEUROBIOLOGY--CHILD DEVELOPMENT, AND DISEASE PATTERNS IN PRIMITIVE CULTURE

神经生物学——原始文化中的儿童发育和疾病模式

• 批准号: 3860743
• 负责人: D CARLETON GAJDUSEK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3860743
• 关键词: HIV infections; child (0-11); child physical development; child psychology; data collection; developmental neurobiology; environmental adaptation; evolution; human T cell lymphotropic virus type 1; human population study; human subject; human tissue; interview; latent virus infection; learning; pathologic process; psychological stressor; respiratory disorder; social behavior; virus diseases

Studies of human biology of vanishing primitive societies focus on neurological development and learning patterns in diverse cultural experiments in the human condition found in such isolated groups. Opportunistic investigation of problems phrased by man in isolation is the basis of approach from which most of our studies evolved: kuru-CJD, HIV (AIDS), HTLV-I slow virus infections of the CNS, aging and Alzheimer's, VE, A LS/PD. Techniques of molecular genetics, biochemistry, immunology, virology, and field epidemiologic, clinical, linguistic and behavioral studies in cultural isolates and genetic and/or geographically isolated primitive bands yield more easily interpretable data than in cosmopolitan societies. Data and specimens from expeditions to Micronesia, Melanesia, Polynesia, South America, Asia and Africa proved valuable in recent HIV (AIDS), HTLV-I, Hantavirus, JC virus of PML and herpesvirus, CMV and EBV studies. Studies on nutrition, reproduction, fertility, age of puberty and aging, genetic distance and pleomorphisms, unusual and odd higher cortical functions in language learning, cognitive styles, computation (calculation without words or numbers) and culturally modified sexual behavior elucidate alternative forms of neurologic functioning for man which we are unable to investigate once the natural cultural experiments in primitive human isolates are amalgamated into the cosmopolitan community of man. Foci of high incidence of kuru, ALS/PD, HTLV-I myelopathy, epilepsy, familial parkinsonism, Viliuisk encephalopathy, other CNS degenerations, hysterical disorders, schizophrenia, bipolar psychoses, neoplasms, goiter, cretinism, rheumatoid diseases, diabetes, asthma, chronic lung disease, malaria, filariasis, leprosy, cysticercosis, and other infections in these isolated groups have yielded widely significant discoveries. HFRS caused by hantaviruses in Asia, USSR, Europe and newly recognized hantaviruses in the U.S. are studied. Human evolution and adaptability to high altitude, wet or arid climes, variable food supply, mineral deficiencies, toxic exposures and responses to severe diseases or social/psychological stress are studied in appropriate population. Thus, HTLV-l and HIV retroviruses as causes of CNS diseases in man were first found in isolated or socially segregated groups, high incidence TSP focus in Tumaco, Colombia; drug-using mothers in Newark, New Jersey, and are often best studied in these isolated or socially segregated groups. We now have a proto-Melanesian quasispecies of HTLV-I in New Guinea, Solomon Islands, Vanautu of an archaic origin, not associated with monkeys at least for milenia.

对正在消失的原始社会的人类生物学的研究重点是 不同文化中的神经发育和学习模式 在人类条件下的实验中发现了这样的孤立群体。 对孤立的人提出的问题进行机会主义的调查是 我们大多数研究的基础方法是：kuru-CJD， HIV（艾滋病）、HTLV-I 可以减缓中枢神经系统的病毒感染、衰老和 阿尔茨海默病、VE、LS/PD。 分子遗传学技术， 生物化学、免疫学、病毒学和现场流行病学、临床、 文化隔离和遗传和/或的语言和行为研究 地理上孤立的原始带更容易解释 数据比国际化社会更重要。 探险数据和标本 密克罗尼西亚、美拉尼西亚、波利尼西亚、南美洲、亚洲和非洲 最近在HIV（艾滋病）、HTLV-I、汉坦病毒、PML的JC病毒中被证明有价值 以及疱疹病毒、CMV 和 EBV 研究。 营养研究， 生殖、生育力、青春期和衰老年龄、遗传距离和 语言中的多态性、不寻常和奇怪的高级皮层功能 学习、认知方式、计算（无需文字或文字的计算） 数字）和文化改变的性行为阐明了替代方案 我们无法了解的人类神经功能形式 调查一次原始人类的自然文化实验 孤立的人融入了人类的世界性社区。 焦点 库鲁病、ALS/PD、HTLV-I 脊髓病、癫痫、家族性的高发病率 帕金森病、Viliuisk 脑病、其他中枢神经系统变性、 癔症、精神分裂症、躁郁症、肿瘤、 甲状腺肿、呆小病、类风湿病、糖尿病、哮喘、慢性肺病 疾病、疟疾、丝虫病、麻风病、囊尾蚴病等 这些孤立群体的感染产生了广泛的重大影响 发现。 HFRS 在亚洲、苏联、欧洲和新近由汉坦病毒引起 对美国公认的汉坦病毒进行了研究。 人类进化和 对高海拔、潮湿或干旱气候、可变食物供应的适应能力， 矿物质缺乏、有毒物质暴露和对严重疾病的反应或 在适当人群中研究社会/心理压力。 因此， HTLV-1 和 HIV 逆转录病毒首次成为人类中枢神经系统疾病的病因 发现于孤立或社会隔离群体中，高发 TSP 焦点 哥伦比亚图马科；新泽西州纽瓦克市的吸毒母亲 通常最好在这些孤立或社会隔离的群体中进行研究。 我们 现在在新几内亚、所罗门有 HTLV-I 的原始美拉尼西亚准种 瓦努阿图群岛的古老起源，与猴子无关 至少对于米莱尼亚来说是这样。