CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS
批准号:
3945164
负责人:
D CARLETON GAJDUSEK
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Alzheimer's disease Huntington's disease Parkinson's disease autism autoimmune disorder biopsy brain neoplasms central nervous system disorders child (0-11) chronic disease /disorder communicable disease transmission congenital neuromuscular disorder degenerative motor system disease dementia electrofocusing electron microscopy encephalitis encephalitis virus genetic disorder human morbidity human population genetics human subject human tissue iatrogenic disease immunofluorescence technique international cooperation interview latent virus infection multiple sclerosis muscular dystrophy myelinopathy nervous system disorder diagnosis nervous system disorder epidemiology nervous system infection neuromuscular disorder diagnosis neurotropic virus occupational hazard paralysis partial seizure postmortem prions progressive multifocal leukoencephalopathy psychobiology schizophrenia scrapie serology /serodiagnosis spongiform encephalopathy subacute sclerosing panencephalitis tissue /cell culture virus antigen virus classification virus cytopathogenic effect virus infection mechanism virus replication zoonosis
中文摘要
研究阐明慢性退行性变的病因和发病机制
以多发性硬化症、肌萎缩侧索硬化症、帕金森氏症为重点的中枢神经系统疾病-
痴呆症、帕金森氏症、匹克氏症和阿尔茨海默氏症,
亨廷顿舞蹈症,核上性麻痹,其他老年前期
痴呆、脊髓小脑性共济失调、癫痫、慢性脑炎
有局灶性癫痫,肌肉营养不良,慢性精神分裂症,
自闭症、SSPE、PML、透析性脑病和颅内
肿瘤。即使是明显的家族性遗传性疾病也可能
减缓病毒感染。亚急性海绵状病毒
脑病:库鲁病和克雅氏病
人;瘙痒病和水貂脑病是由
具有独特特性的非常规病毒构成重要的
微生物学和分子生物学的理论问题;a
主要目的是阐明它们的结构和机制。
复制。传染性病毒性痴呆症越来越多
全球公认的死因:高发疫源地,
通过角膜移植或脑部手术传播,以及
接触患病或传染性疾病造成的职业危害
大脑。为了确定通常的感染模式
这种病毒,一项关于传染性疾病的全球流行病学研究
病毒性痴呆症(CJD)病例正在进行中,并特别关注
家族聚集性病例,并寻求可能的
羊瘙痒病与人类疾病的关系。
家族性和非家族性痴呆与老年性痴呆
并对其进行了研究。对特定脑组织的自身免疫反应
中枢神经系统疾病的抗原正在深入研究中。脱氧核糖核酸
金黄色葡萄球菌的原位杂交和电泳聚焦分配
蛋白质、酶和杂交瘤
免疫荧光和许多其他技术被用来尝试
鉴定组织中的病毒亚基和部分基因组
慢性病。
英文摘要
Studies elucidate cause and pathogenesis of chronic degenerative
CNS disorders with emphasis on MS, ALS, Parkinsonism-
dementia, Parkinson's, Pick's, and Alzheimer's disease,
Huntington's chorea, supranuclear palsy, other presenile
dementias, spinocerebellar ataxias, epilepsy, chronic encephalitis
with focal epilepsy, muscular dystrophies, chronic schizophrenia,
autism, SSPE, PML, dialysis encephalopathy, and intracranial
neoplasm. Even familial, apparently hereditary diseases may be
slow virus infections. Subacute spongiform virus
encephalopathies: kuru and Creutzfeldt-Jakob disease (CJD) of
man; scrapie and mink encephalopathy are caused by
unconventional viruses with unique properties posing important
theoretical problems to microbiology and molecular biology; a
major goal is elucidation of their structure and mechanisms of
replication. Transmissible virus dementias are increasingly
recognized worldwide causes of death: high incidence foci,
transmission by corneal transplant or brain surgery, and
occupational hazards from exposure to diseased or infectious
brain. In order to determine the usual mode of infection with
the virus, a worldwide epidemiological study of tranmissible
virus dementia (CJD) cases in underway with special attention to
familial clusters of cases and with a quest for possible
relationship of scrapie of sheep to the human disease.
Familial and nonfamilial dementia and the dementias of senility
are studied. The autoimmune responses to specific brain
antigens in CNS diseases are under intensive investigation. DNA
in situ hybridization and electrophoretic focusing partition of
proteins along with enzymatic and hybridoma
immunofluorescence and many other techniques are used to try
to identify viral subunits and partial genomes in tissues in
chronic diseases.
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会议论文
NEUROBIOLOGY--CHILD DEVELOPMENT, AND DISEASE PATTERNS IN PRIMITIVE CULTURE
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批准号:3922456
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTION
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批准号:3782280
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS
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批准号:3881664
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
NEUROBIOLOGY--CHILD DEVELOPMENT, AND DISEASE PATTERNS IN PRIMITIVE CULTURE
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批准号:3860743
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTION
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批准号:5203872
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS
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批准号:3860741
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTION
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批准号:2579500
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
NEUROBIOLOGY--CHILD DEVELOPMENT, AND DISEASE PATTERNS IN PRIMITIVE CULTURE
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批准号:3968884
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
NEUROBIOLOGY--CHILD DEVELOPMENT, AND DISEASE PATTERNS IN PRIMITIVE CULTURE
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批准号:3945167
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS
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批准号:3968879
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
NEUROBIOLOGY--CHILD DEVELOPMENT, AND DISEASE PATTERNS IN PRIMITIVE CULTURE
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批准号:3881666
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS
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批准号:3922452
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
NEUROBIOLOGY--CHILD DEVELOPMENT, AND DISEASE PATTERNS IN PRIMITIVE CULTURE
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批准号:4696782
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS
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批准号:4696777
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
PRIMITIVE POPULATIONS--CHILD DEVELOPMENT,BEHAVIOR,AND DISEASE PATTERNS
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批准号:5203874
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTION
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批准号:3760199
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:D CARLETON GAJDUSEK
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依托单位:
海外基金