CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS

慢性中枢神经系统疾病研究——缓慢、潜伏和温带病毒感染

• 批准号: 3945164
• 负责人: D CARLETON GAJDUSEK
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3945164
• 关键词: Alzheimer's disease; Huntington's disease; Parkinson's disease; autism; autoimmune disorder; biopsy; brain neoplasms; central nervous system disorders; child (0-11); chronic disease /disorder; communicable disease transmission; congenital neuromuscular disorder; degenerative motor system disease; dementia; electrofocusing; electron microscopy; encephalitis; encephalitis virus; genetic disorder; human morbidity; human population genetics; human subject; human tissue; iatrogenic disease; immunofluorescence technique; international cooperation; interview; latent virus infection; multiple sclerosis; muscular dystrophy; myelinopathy; nervous system disorder diagnosis; nervous system disorder epidemiology; nervous system infection; neuromuscular disorder diagnosis; neurotropic virus; occupational hazard; paralysis; partial seizure; postmortem; prions; progressive multifocal leukoencephalopathy; psychobiology; schizophrenia; scrapie; serology /serodiagnosis; spongiform encephalopathy; subacute sclerosing panencephalitis; tissue /cell culture; virus antigen; virus classification; virus cytopathogenic effect; virus infection mechanism; virus replication; zoonosis

Studies elucidate cause and pathogenesis of chronic degenerative CNS disorders with emphasis on MS, ALS, Parkinsonism- dementia, Parkinson's, Pick's, and Alzheimer's disease, Huntington's chorea, supranuclear palsy, other presenile dementias, spinocerebellar ataxias, epilepsy, chronic encephalitis with focal epilepsy, muscular dystrophies, chronic schizophrenia, autism, SSPE, PML, dialysis encephalopathy, and intracranial neoplasm. Even familial, apparently hereditary diseases may be slow virus infections. Subacute spongiform virus encephalopathies: kuru and Creutzfeldt-Jakob disease (CJD) of man; scrapie and mink encephalopathy are caused by unconventional viruses with unique properties posing important theoretical problems to microbiology and molecular biology; a major goal is elucidation of their structure and mechanisms of replication. Transmissible virus dementias are increasingly recognized worldwide causes of death: high incidence foci, transmission by corneal transplant or brain surgery, and occupational hazards from exposure to diseased or infectious brain. In order to determine the usual mode of infection with the virus, a worldwide epidemiological study of tranmissible virus dementia (CJD) cases in underway with special attention to familial clusters of cases and with a quest for possible relationship of scrapie of sheep to the human disease. Familial and nonfamilial dementia and the dementias of senility are studied. The autoimmune responses to specific brain antigens in CNS diseases are under intensive investigation. DNA in situ hybridization and electrophoretic focusing partition of proteins along with enzymatic and hybridoma immunofluorescence and many other techniques are used to try to identify viral subunits and partial genomes in tissues in chronic diseases.

研究阐明了慢性退行性变的原因和发病机制 中枢神经系统疾病，重点是MS、ALS、帕金森综合征- 痴呆症、帕金森氏症、皮克氏症和阿尔茨海默氏症， 亨廷顿舞蹈病、核上性麻痹、其他早老性 痴呆、脊髓小脑共济失调、癫痫、慢性脑炎 有局灶性癫痫，肌肉萎缩症，慢性精神分裂症， 自闭症、SSPE、PML、透析性脑病和颅内 肿瘤。 即使是家族性的，明显的遗传性疾病， 减缓病毒感染。 亚急性海绵状病毒 库鲁病和克雅氏病（CJD） 男人;瘙痒症和水貂脑病是由 具有独特特性的非常规病毒 微生物学和分子生物学的理论问题; 主要目的是阐明其结构和机制， 复制的 传染性病毒性痴呆越来越多地 全球公认的死亡原因：高发病率病灶， 通过角膜移植或脑部手术传播，以及 职业性接触疾病或传染病的危害 个脑袋 为了确定感染的常见模式 该病毒是一项全球性的传染性 病毒性痴呆症（克雅二氏症）的个案，并特别注意 家族聚集性病例， 羊瘙痒症与人类疾病的关系。 家族性和非家族性痴呆与老年痴呆 进行了研究 对特定脑组织的自身免疫反应 中枢神经系统疾病中的抗原正在深入研究中。 DNA 原位杂交和电泳聚焦分离 蛋白质沿着酶和杂交瘤 免疫荧光和许多其他技术被用来尝试 以鉴定组织中的病毒亚单位和部分基因组， 慢性病