CHRONIC CNS DISEASE STUDIES--SLOW, LATENT AND TEMPERATE VIRUS INFECTIONS

研究阐明慢性退行性变的病因和发病机制 以多发性硬化症、肌萎缩侧索硬化症、帕金森氏症为重点的中枢神经系统疾病- 痴呆症、帕金森氏症、匹克氏症和阿尔茨海默氏症， 亨廷顿舞蹈症，核上性麻痹，其他老年前期 痴呆、脊髓小脑性共济失调、癫痫、慢性脑炎 有局灶性癫痫，肌肉营养不良，慢性精神分裂症， 自闭症、SSPE、PML、透析性脑病和颅内 肿瘤。即使是明显的家族性遗传性疾病也可能 减缓病毒感染。亚急性海绵状病毒 脑病：库鲁病和克雅氏病 人；瘙痒病和水貂脑病是由 具有独特特性的非常规病毒构成重要的 微生物学和分子生物学的理论问题；a 主要目的是阐明它们的结构和机制。 复制。传染性病毒性痴呆症越来越多 全球公认的死因：高发疫源地， 通过角膜移植或脑部手术传播，以及 接触患病或传染性疾病造成的职业危害 大脑。为了确定通常的感染模式 这种病毒，一项关于传染性疾病的全球流行病学研究 病毒性痴呆症(CJD)病例正在进行中，并特别关注 家族聚集性病例，并寻求可能的 羊瘙痒病与人类疾病的关系。 家族性和非家族性痴呆与老年性痴呆 并对其进行了研究。对特定脑组织的自身免疫反应 中枢神经系统疾病的抗原正在深入研究中。脱氧核糖核酸 金黄色葡萄球菌的原位杂交和电泳聚焦分配 蛋白质、酶和杂交瘤 免疫荧光和许多其他技术被用来尝试 鉴定组织中的病毒亚基和部分基因组 慢性病。

Studies elucidate cause and pathogenesis of chronic degenerative CNS disorders with emphasis on MS, ALS, Parkinsonism- dementia, Parkinson's, Pick's, and Alzheimer's disease, Huntington's chorea, supranuclear palsy, other presenile dementias, spinocerebellar ataxias, epilepsy, chronic encephalitis with focal epilepsy, muscular dystrophies, chronic schizophrenia, autism, SSPE, PML, dialysis encephalopathy, and intracranial neoplasm. Even familial, apparently hereditary diseases may be slow virus infections. Subacute spongiform virus encephalopathies: kuru and Creutzfeldt-Jakob disease (CJD) of man; scrapie and mink encephalopathy are caused by unconventional viruses with unique properties posing important theoretical problems to microbiology and molecular biology; a major goal is elucidation of their structure and mechanisms of replication. Transmissible virus dementias are increasingly recognized worldwide causes of death: high incidence foci, transmission by corneal transplant or brain surgery, and occupational hazards from exposure to diseased or infectious brain. In order to determine the usual mode of infection with the virus, a worldwide epidemiological study of tranmissible virus dementia (CJD) cases in underway with special attention to familial clusters of cases and with a quest for possible relationship of scrapie of sheep to the human disease. Familial and nonfamilial dementia and the dementias of senility are studied. The autoimmune responses to specific brain antigens in CNS diseases are under intensive investigation. DNA in situ hybridization and electrophoretic focusing partition of proteins along with enzymatic and hybridoma immunofluorescence and many other techniques are used to try to identify viral subunits and partial genomes in tissues in chronic diseases.